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Overview

Uniprot IDA0A8D1GLE8
Protein NameFour and a half LIM domains protein 3
Gene NameFHL3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
167 CVPCYENKFAPRCAR
177 PRCARCSKTLTQGGV
245 ITGLGGGKYVSFEDR

Function

Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1

Protein Sequence

10 MQQEGSITAT 20 MSETFDCAKC 30 SESLYGRKYI 40 QTDNGPYCVP 50 CYDNTFANTC 60 AECQQLIGHD 70 SRELFYEDRH 80 FHEGCFRCCR 90 CQRSLADEPF 100 TCQDSELLCN 110 DCYCSAFSSQ 120 CSACGETVMP 130 GSRKLEYGGQ 140 TWHEHCFLCS 150 GCEQPLGSCS 160 FVPDKGAHYC 170 VPCYENKFAP 180 RCARCSKTLT 190 QGGVTYRDQP 200 WHRECLVCTG 210 CQTPLAGQQF 220 TSRDDDPYCV 230 ACFGELFAPK 240 CSSCKRPITG 250 LGGGKYVSFE 260 DRHWHHSCFS 270 CARCSTSLVG 280 QGFVPDGDQV 290 LCQGCSQAGP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.