Search Results
Overview
| Uniprot ID | A0A8D1IV93 |
|---|---|
| Protein Name | Ras GTPase-activating-like protein IQGAP1 |
| Gene Name | IQGAP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | LCHLEEAKRWMEACL |
| 1079 | YLLLRLFKTALQEEI |
| 1087 | TALQEEIKSKVDQIQ |
| 1140 | DDKSLNIKTDPVDIY |
| 1220 | RFIAKVLKDSLHEKF |
| 1226 | LKDSLHEKFPDAGED |
| 1441 | RTILLNTKRLIVDVI |
| 1497 | MKKSKSVKEDSNLTL |
| 1507 | SNLTLQEKKEKIQSG |
| 1516 | EKIQSGLKKLTELGT |
| 1517 | KIQSGLKKLTELGTV |
| 1527 | ELGTVDPKNRYQELI |
| 156 | DREQTRYKATGLHFR |
| 1584 | DYYKSYIKTCLDNLA |
| 1593 | CLDNLASKGKVSKKP |
| 1614 | KSKKISLKYTAARLH |
| 736 | AAGDNNSKWVKHWVK |
| 739 | DNNSKWVKHWVKGGY |
| 826 | SRMNFLKKQIPAITC |
| 858 | LAYLRSHKDEVIKIQ |
| 863 | SHKDEVIKIQSLARM |
| 974 | IKIGLLVKNKITLQD |
| 976 | IGLLVKNKITLQDVV |
Function
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest
Protein Sequence
10
MWLGTSGKSG
20
LPGHCLESPL
30
RGYYPAQLEE
40
WALNGISRPS
50
VISHLEQKEE
60
PWILPLQNFE
70
ASKIQRESHT
80
AVLDNERLTA
90
EEMDERRRQN
100
VAYEYLCHLE
110
EAKRWMEACL
120
GEDLPPTTEL
130
EEGLRNGVYL
140
AKLGNFFSPK
150
VVSLKKIYDR
160
EQTRYKATGL
170
HFRHTDNVIQ
180
WLNAMGEIGL
190
PKIFYPETTD
200
IYDRKNMPRC
210
IYCIHALSLY
220
LFKLGLAPQI
230
QDLYGKVDFT
240
EEEINNMKIE
250
LEKYGIQMPA
260
FSKIGGILAN
270
ELSVDEAALH
280
AAVIAINEAI
290
DHRIPADTFT
300
ALKNPNAMLV
310
NLEEPLASTY
320
QDVLYQAKQD
330
KMTNAKNRTE
340
SSERERDVYE
350
ELLTQAEIQG
360
NINKVNMIAA
370
LANVDQALEQ
380
GSALALFKIL
390
QSPALGLRGL
400
QQQNSDWYLK
410
QLLSDRQQKR
420
ESGQAEPLQK
430
EELQSGVDAG
440
NIAAQQYQRR
450
LAAVAAINAA
460
IQKGVAEKTV
470
LELMNPEAQL
480
PQVYPFAAEL
490
YQKELATLQQ
500
QSPEHSLTHP
510
ELSVAVEMLS
520
SVALINRALE
530
SGDMNTVWRQ
540
LSSSVTGLTN
550
IEEENYQRYL
560
DELMKLKAQA
570
HAENNEFITW
580
NDIQACVDHV
590
NLVVQEEHER
600
ILAIGLINEA
610
LDEGDAQKTL
620
QALQTPAAKL
630
EGVLAEVAQH
640
YQDTLIRAKR
650
EKAQETQDES
660
AVLWLDEIQG
670
GIWQSNKDTQ
680
EAQKFALGIF
690
AINEAVDSGD
700
VSRTLSALRS
710
PDVGLYGVIP
720
ECGQTYQSDL
730
AEAKKKKLAA
740
GDNNSKWVKH
750
WVKGGYYYYH
760
NLETQEGGWD
770
EPPDFVQNFM
780
QLSREEIQSS
790
ISGVTAAYNR
800
EQLWLANEGL
810
ITRLQACCRG
820
YLVRQEFRSR
830
MNFLKKQIPA
840
ITCIQSQWRG
850
YKQKKAYQDR
860
LAYLRSHKDE
870
VIKIQSLARM
880
HQARKRYRDR
890
LQYFRDHIND
900
IIKIQAFIRA
910
NKARDDYKTL
920
INAEDPPMIV
930
VRKFVHLLDQ
940
SDQDFQEELD
950
LMKMREEVIT
960
LIRSNQQLEN
970
DLNLMDIKIG
980
LLVKNKITLQ
990
DVVSHSKKLT
1000
KKNKEQLSDM
1010
MMLNKQKGGL
1020
KALSKEKREK
1030
LEAYQHLFYL
1040
LQTNPTYLAK
1050
LIFQMPQNKS
1060
TKFMDSVIFT
1070
LYNYASNQRE
1080
EYLLLRLFKT
1090
ALQEEIKSKV
1100
DQIQEIVTGN
1110
PTVIKMVVSF
1120
NRGARGQNAL
1130
RQILAPVVKE
1140
IMDDKSLNIK
1150
TDPVDIYKSW
1160
VNQMESQTGE
1170
ASKLPYDVTP
1180
EQALAHEEVR
1190
TRLDNSIRNM
1200
RAVTDKFLAA
1210
IISSVDKIPY
1220
GMRFIAKVLK
1230
DSLHEKFPDA
1240
GEDELLKIIG
1250
NLLYYRYMNP
1260
AIVAPDAFDI
1270
IDLSAGGQLT
1280
TDQRRNLGSI
1290
AKMLQHAASN
1300
KMFLGDNAHL
1310
SIINEYLSQS
1320
YQKFRRFFQT
1330
ACDVPELQDK
1340
FNVDEYSDLV
1350
TLTKPVIYIS
1360
IGEIINTHTL
1370
LLDHQDAIAP
1380
EHNDPIHELL
1390
DDLGEVPTIE
1400
SLIGEGSGNV
1410
NDPNKEALAK
1420
TEVSLTLTNK
1430
FDVPGDENAE
1440
MDARTILLNT
1450
KRLIVDVIRF
1460
QPGETLTEIL
1470
ETPATSEQEA
1480
EHQRAMQRRA
1490
IRDAKTPDKM
1500
KKSKSVKEDS
1510
NLTLQEKKEK
1520
IQSGLKKLTE
1530
LGTVDPKNRY
1540
QELINDIAKD
1550
IRNQRRYRQR
1560
RKAELVKLQQ
1570
TYAALNSKAT
1580
FYGEQVDYYK
1590
SYIKTCLDNL
1600
ASKGKVSKKP
1610
REMKGKKSKK
1620
ISLKYTAARL
1630
HEKGVLLEIE
1640
DLQVNQFKNV
1650
IFEISPTEEV
1660
GDFEVKAKFM
1670
GVQMETFMLH
1680
YQDLLQLQYE
1690
GVAVMKLFDR
1700
AKVNVNLLIF
LLNKKFYGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016328 | lateral plasma membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005078 | MAP-kinase scaffold activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0070836 | caveola assembly |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0007173 | epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| Biological Process | GO:0010761 | fibroblast migration |
| Biological Process | GO:1903479 | mitotic actomyosin contractile ring assembly actin filament organization |
| Biological Process | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0043410 | positive regulation of MAPK cascade |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0007346 | regulation of mitotic cell cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.