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Overview

Uniprot IDA0A8D1IV93
Protein NameRas GTPase-activating-like protein IQGAP1
Gene NameIQGAP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
103 LCHLEEAKRWMEACL
1079 YLLLRLFKTALQEEI
1087 TALQEEIKSKVDQIQ
1140 DDKSLNIKTDPVDIY
1220 RFIAKVLKDSLHEKF
1226 LKDSLHEKFPDAGED
1441 RTILLNTKRLIVDVI
1497 MKKSKSVKEDSNLTL
1507 SNLTLQEKKEKIQSG
1516 EKIQSGLKKLTELGT
1517 KIQSGLKKLTELGTV
1527 ELGTVDPKNRYQELI
156 DREQTRYKATGLHFR
1584 DYYKSYIKTCLDNLA
1593 CLDNLASKGKVSKKP
1614 KSKKISLKYTAARLH
736 AAGDNNSKWVKHWVK
739 DNNSKWVKHWVKGGY
826 SRMNFLKKQIPAITC
858 LAYLRSHKDEVIKIQ
863 SHKDEVIKIQSLARM
974 IKIGLLVKNKITLQD
976 IGLLVKNKITLQDVV

Function

Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest

Protein Sequence

10 MWLGTSGKSG 20 LPGHCLESPL 30 RGYYPAQLEE 40 WALNGISRPS 50 VISHLEQKEE 60 PWILPLQNFE 70 ASKIQRESHT 80 AVLDNERLTA 90 EEMDERRRQN 100 VAYEYLCHLE 110 EAKRWMEACL 120 GEDLPPTTEL 130 EEGLRNGVYL 140 AKLGNFFSPK 150 VVSLKKIYDR 160 EQTRYKATGL 170 HFRHTDNVIQ 180 WLNAMGEIGL 190 PKIFYPETTD 200 IYDRKNMPRC 210 IYCIHALSLY 220 LFKLGLAPQI 230 QDLYGKVDFT 240 EEEINNMKIE 250 LEKYGIQMPA 260 FSKIGGILAN 270 ELSVDEAALH 280 AAVIAINEAI 290 DHRIPADTFT 300 ALKNPNAMLV 310 NLEEPLASTY 320 QDVLYQAKQD 330 KMTNAKNRTE 340 SSERERDVYE 350 ELLTQAEIQG 360 NINKVNMIAA 370 LANVDQALEQ 380 GSALALFKIL 390 QSPALGLRGL 400 QQQNSDWYLK 410 QLLSDRQQKR 420 ESGQAEPLQK 430 EELQSGVDAG 440 NIAAQQYQRR 450 LAAVAAINAA 460 IQKGVAEKTV 470 LELMNPEAQL 480 PQVYPFAAEL 490 YQKELATLQQ 500 QSPEHSLTHP 510 ELSVAVEMLS 520 SVALINRALE 530 SGDMNTVWRQ 540 LSSSVTGLTN 550 IEEENYQRYL 560 DELMKLKAQA 570 HAENNEFITW 580 NDIQACVDHV 590 NLVVQEEHER 600 ILAIGLINEA 610 LDEGDAQKTL 620 QALQTPAAKL 630 EGVLAEVAQH 640 YQDTLIRAKR 650 EKAQETQDES 660 AVLWLDEIQG 670 GIWQSNKDTQ 680 EAQKFALGIF 690 AINEAVDSGD 700 VSRTLSALRS 710 PDVGLYGVIP 720 ECGQTYQSDL 730 AEAKKKKLAA 740 GDNNSKWVKH 750 WVKGGYYYYH 760 NLETQEGGWD 770 EPPDFVQNFM 780 QLSREEIQSS 790 ISGVTAAYNR 800 EQLWLANEGL 810 ITRLQACCRG 820 YLVRQEFRSR 830 MNFLKKQIPA 840 ITCIQSQWRG 850 YKQKKAYQDR 860 LAYLRSHKDE 870 VIKIQSLARM 880 HQARKRYRDR 890 LQYFRDHIND 900 IIKIQAFIRA 910 NKARDDYKTL 920 INAEDPPMIV 930 VRKFVHLLDQ 940 SDQDFQEELD 950 LMKMREEVIT 960 LIRSNQQLEN 970 DLNLMDIKIG 980 LLVKNKITLQ 990 DVVSHSKKLT 1000 KKNKEQLSDM 1010 MMLNKQKGGL 1020 KALSKEKREK 1030 LEAYQHLFYL 1040 LQTNPTYLAK 1050 LIFQMPQNKS 1060 TKFMDSVIFT 1070 LYNYASNQRE 1080 EYLLLRLFKT 1090 ALQEEIKSKV 1100 DQIQEIVTGN 1110 PTVIKMVVSF 1120 NRGARGQNAL 1130 RQILAPVVKE 1140 IMDDKSLNIK 1150 TDPVDIYKSW 1160 VNQMESQTGE 1170 ASKLPYDVTP 1180 EQALAHEEVR 1190 TRLDNSIRNM 1200 RAVTDKFLAA 1210 IISSVDKIPY 1220 GMRFIAKVLK 1230 DSLHEKFPDA 1240 GEDELLKIIG 1250 NLLYYRYMNP 1260 AIVAPDAFDI 1270 IDLSAGGQLT 1280 TDQRRNLGSI 1290 AKMLQHAASN 1300 KMFLGDNAHL 1310 SIINEYLSQS 1320 YQKFRRFFQT 1330 ACDVPELQDK 1340 FNVDEYSDLV 1350 TLTKPVIYIS 1360 IGEIINTHTL 1370 LLDHQDAIAP 1380 EHNDPIHELL 1390 DDLGEVPTIE 1400 SLIGEGSGNV 1410 NDPNKEALAK 1420 TEVSLTLTNK 1430 FDVPGDENAE 1440 MDARTILLNT 1450 KRLIVDVIRF 1460 QPGETLTEIL 1470 ETPATSEQEA 1480 EHQRAMQRRA 1490 IRDAKTPDKM 1500 KKSKSVKEDS 1510 NLTLQEKKEK 1520 IQSGLKKLTE 1530 LGTVDPKNRY 1540 QELINDIAKD 1550 IRNQRRYRQR 1560 RKAELVKLQQ 1570 TYAALNSKAT 1580 FYGEQVDYYK 1590 SYIKTCLDNL 1600 ASKGKVSKKP 1610 REMKGKKSKK 1620 ISLKYTAARL 1630 HEKGVLLEIE 1640 DLQVNQFKNV 1650 IFEISPTEEV 1660 GDFEVKAKFM 1670 GVQMETFMLH 1680 YQDLLQLQYE 1690 GVAVMKLFDR 1700 AKVNVNLLIF LLNKKFYGK

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0009898 cytoplasmic side of plasma membrane
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0030496 midbody
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0001726 ruffle
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005078 MAP-kinase scaffold activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0019903 protein phosphatase binding
Molecular Function GO:0043539 protein serine/threonine kinase activator activity
Molecular Function GO:0044548 S100 protein binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0070836 caveola assembly
Biological Process GO:0071277 cellular response to calcium ion
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0010761 fibroblast migration
Biological Process GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0007346 regulation of mitotic cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.