Overview
| Uniprot ID | A0A8D1JEA8 |
|---|
| Protein Name | DnaJ homolog subfamily C member 2 |
|---|
| Gene Name | DNAJC2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 505 |
KAFDKFKKEHGVVPQ |
Function
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation
Protein Sequence
10
MLLLPSAADG
20
QSTAITHALT
30
SASTFCQVEP
40
VGRWFEAFVK
50
RRNRNASASF
60
QELEDKKELS
70
EESEDEELQL
80
EEFPMLKTLD
90
PKDWKNQDHY
100
AVLGLGHVRY
110
KATQRQIKAA
120
HKAMVLKHHP
130
DKRKAAGEPI
140
KEGDNDYFTC
150
ITKAYEMLSD
160
PVKRRAFNSV
170
DPTFDNSVPS
180
KSEAKDNFFE
190
VFSPVFERNS
200
RWSNKKNVPK
210
LGDMNSSFED
220
VDAFYSFCRD
230
ERRWIEKQNR
240
ATRAQRKKEE
250
MNRIRTLVDN
260
AYSCDPRIKK
270
FKEEEKAKKE
280
AEKKAKAEAK
290
RKEQEAKEKQ
300
RQAELEAARL
310
AKEKEEEEVR
320
QQALLAKKEK
330
DIQKKAIKKE
340
RQKLRNSCKT
350
WNHFSDNEAE
360
RVKMMEEVEK
370
LCDRLELSSL
380
QCLNETLTSS
390
TKEVGKAALE
400
KQIEEINEQI
410
RKEKEEAEAR
420
MRQASKNAEK
430
STGGGGNGSK
440
HWSEDDLQLL
450
IKAVNLFPAG
460
TNSRWEVIAN
470
YMNIHSSSGV
480
KRTAKDVIGK
490
AKSLQKLDPH
500
QKDDINKKAF
510
DKFKKEHGVV
520
PQADNATPSE
530
RFEGPCTDFT
540
PWTTEEQKLL
550
EQALKTYPVN
560
TPERWEKIAE
570
AVPGRTKKDC
580
MKRYKELVEM
590
VKAKKAAQEQ
VLNASRAKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005730 |
nucleolus |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0030544 |
Hsp70 protein binding |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Molecular Function |
GO:0061649 |
ubiquitin-modified histone reader activity |
| Biological Process |
GO:0051083 |
'de novo' cotranslational protein folding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0006450 |
regulation of translational fidelity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.