Search Results
Overview
| Uniprot ID | A0A8D1JQV5 |
|---|---|
| Protein Name | S-methyl-5'-thioadenosine phosphorylase |
| Gene Name | MTAP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 130 | EVLIETAKKLGLRCH |
| 139 | LGLRCHSKGTMITIE |
| 214 | DRVLKTLKENANKAK |
| 22 | SDALILGKIKNVDCV |
| 24 | ALILGKIKNVDCVLL |
| 5 | ***GRTEKYVDTPFG |
| 92 | QFIDRTTKRPQTFYD |
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates
Protein Sequence
10
GRTEKYVDTP
20
FGKPSDALIL
30
GKIKNVDCVL
40
LARHGRQHTI
50
MPSKVNYQAN
60
IWALKEEGCT
70
HIIVTTACGS
80
LKEEIQPGDF
90
IIIDQFIDRT
100
TKRPQTFYDG
110
NHSCARGVCH
120
IPMAEPFCPK
130
TREVLIETAK
140
KLGLRCHSKG
150
TMITIEGPRF
160
SSRAESLTFQ
170
TWGADVINMT
180
TVPEVVLAKE
190
AGICYASIAM
200
ATDYDCWKEH
210
EEVVSVDRVL
220
KTLKENANKA
230
KSLLLTTIPQ
240
IGSMEWSETL
250
HNLKIGSFSV
LVLNP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0017061 | S-methyl-5-thioadenosine phosphorylase activity |
| Biological Process | GO:0019509 | L-methionine salvage from methylthioadenosine |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.