Search Results
Overview
| Uniprot ID | A0A8D1KH88 |
|---|---|
| Protein Name | Polypeptide N-acetylgalactosaminyltransferase |
| Gene Name | GALNT2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 320 | LRKKLSCKPFKWYLE |
| 405 | RAPGSLIKLQGCREN |
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism
Protein Sequence
10
MDWKLKKISY
20
SSGQRGGPIK
30
RCQRKQWRVD
40
LPATSVVITF
50
HNEARSALLR
60
TVVSVLKKSP
70
PHLIKEIILV
80
DDYSNDPEDG
90
ALLGKIEKVR
100
VLRNDRREGL
110
MRSRVRGADA
120
AQAKVLTFLD
130
SHCECNEHWL
140
EPLLERVAED
150
RTRVVSPIID
160
VINMDNFQYV
170
GASADLKGGF
180
DWNLVFKWDY
190
MTPEQRRARQ
200
GNPVAPIKTP
210
MIAGGLFVMD
220
KFYFEELGKY
230
DMMMDVWGGE
240
NLEISFRVWQ
250
CGGSLEIIPC
260
SRVGHVFRKQ
270
HPYTFPGGSG
280
TVFARNTRRA
290
AEVWMDEYKN
300
FYYAAVPSAR
310
NVPYGNIQSR
320
LELRKKLSCK
330
PFKWYLENVY
340
PELRVPDHQD
350
IAFGALQQGT
360
NCLDTLGHFA
370
DGVVGVYECH
380
NAGGNQEWAL
390
TKEKSVKHMD
400
LCLTVVDRAP
410
GSLIKLQGCR
420
ENDSRQKWEQ
430
IEGNSKLRHV
440
GSNLCLDSRA
450
AKNGGLSVEV
460
CGPALSQQWK
FSLNLQQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0032580 | Golgi cisterna membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.