Search Results
Overview
| Uniprot ID | A0A8D1L3X4 |
|---|---|
| Protein Name | Peroxiredoxin-5 |
| Gene Name | PRDX5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 31 | FEGEPEKKVNLAELF |
| 72 | VEQAEALKAKGIQVV |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events
Protein Sequence
10
MEPSPLPFPA
20
PIGVGDAIPS
30
VVVFEGEPEK
40
KVNLAELFKG
50
KKGVLFGVPG
60
AFTPGCSKTH
70
LPGFVEQAEA
80
LKAKGIQVVA
90
CLSVNDVFVT
100
EMWGRAHNTE
110
GKVRLLADPT
120
GAFGKETDLL
130
LDDSLVSLFG
140
NRRLKRFSMV
150
IEDGIVKSLN
160
VEPDGTGLTC
170
SLAPNIISQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| Molecular Function | GO:0001016 | RNA polymerase III transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008379 | thioredoxin peroxidase activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0034599 | cellular response to oxidative stress |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0042744 | hydrogen peroxide catabolic process |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0016480 | negative regulation of transcription by RNA polymerase III |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.