Search Results
Overview
| Uniprot ID | A0A8D1M3L0 |
|---|---|
| Protein Name | Aspartate aminotransferase |
| Gene Name | GOT2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | AEAQIAAKNLDKEYL |
| 134 | GENNEVLKSGRYVTV |
| 246 | KEMATLVKKNNLFAF |
| 308 | GAFTVVCKDAEEAKR |
| 321 | KRVESQLKILIRPMY |
| 375 | TQLVSNLKKEGSSHN |
| 94 | YVLPSVRKAEAQIAA |
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids
Protein Sequence
10
MTRPTGPTSL
20
PARAPWTVGE
30
HSNAFPWVRK
40
CGPLRHPDSH
50
SSSWWAHVEM
60
GPPDPILGVT
70
EAFKRDTNSK
80
KMNLGVGAYR
90
DDNGKPYVLP
100
SVRKAEAQIA
110
AKNLDKEYLP
120
IGGLAEFCKA
130
SAELALGENN
140
EVLKSGRYVT
150
VQTISGTGAL
160
RIGANFLQRF
170
FKFSRDVFLP
180
KPSWGNHTPI
190
FRDAGMQLHS
200
YRYYDPKTCG
210
FDFTGALEDI
220
SKIPAQSVIL
230
LHACAHNPTG
240
VDPRPEQWKE
250
MATLVKKNNL
260
FAFFDMAYQG
270
FASGDGNKDA
280
WAVRHFIEQG
290
INVCLCQSYA
300
KNMGLYGERV
310
GAFTVVCKDA
320
EEAKRVESQL
330
KILIRPMYSN
340
PPVNGARIAS
350
TILTSPDLRQ
360
QWLQEVKGMA
370
DRIISMRTQL
380
VSNLKKEGSS
390
HNWQHIVDQI
400
GMFCFTGIKP
410
EQVERLTKEF
420
SIYMTKDGRI
430
SVAGVTSGNV
440
GYLAHAIHQV
TK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0015908 | fatty acid transport |
| Biological Process | GO:0006533 | L-aspartate catabolic process |
| Biological Process | GO:0043490 | malate-aspartate shuttle |
| Biological Process | GO:0045471 | response to ethanol |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.