Search Results
Overview
| Uniprot ID | A0A8D1M6M7 |
|---|---|
| Protein Name | Farnesyl pyrophosphate synthase |
| Gene Name | FDPS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | RELVEPRKQDADSLQ |
| 324 | YGQKDAEKVARVKAL |
| 73 | GDAVARLKEVLEYNV |
| 84 | EYNVVGGKYNRGITV |
Function
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate
Protein Sequence
10
MWLCHSWAGK
20
LGSRCWLQRG
30
AFYSSLRMNG
40
DQKLDAYARE
50
RQDFIQHFSQ
60
IVKVLTEEDI
70
GHPEIGDAVA
80
RLKEVLEYNV
90
VGGKYNRGIT
100
VLVVFRELVE
110
PRKQDADSLQ
120
RALTVGWCIE
130
LLQAFFLVAD
140
DIEDSSLTRR
150
GQTCWYRKPG
160
IGLDAINDAF
170
LLEACIYRLL
180
KFYCREQPYY
190
LNLIELFLQT
200
SYNTEIGQTL
210
DLIAGPQGNV
220
DLSRFTEKRY
230
KSIVKYKTAF
240
YSFYLPVAAA
250
MYMAGIDGEK
260
EHANAKKILM
270
EMGEFFQIQD
280
DYLDLFGDPS
290
VTGKIGTDIQ
300
DNKCSWLVVQ
310
CLQRASPEQR
320
QILQENYGQK
330
DAEKVARVKA
340
LYEEMNLQAV
350
FLQYEEDSYS
360
HLMGLIEQYA
370
APLPPAIFLE
380
LAHKIYKRRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0004337 | (2E,6E)-farnesyl diphosphate synthase activity |
| Molecular Function | GO:0004161 | dimethylallyltranstransferase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0008299 | isoprenoid biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.