Search Results
Overview
| Uniprot ID | A0A8D1P775 |
|---|---|
| Protein Name | Histidine--tRNA ligase, cytoplasmic |
| Gene Name | HARS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | IKRYHIAKVYRRDNP |
| 378 | VLVASAQKKLLEERL |
| 42 | VAKLLKLKAQLGPDE |
| 66 | PKETLTGKYGEDSKL |
Function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance
Protein Sequence
10
MAGRETLEEL
20
VRLQGERVRG
30
LKQQKASTEQ
40
IEEEVAKLLK
50
LKAQLGPDEG
60
KHKFVLKTPK
70
ETLTGKYGED
80
SKLIYDLKDQ
90
GGELLSLRYD
100
LTVPFARYLA
110
MNKLTNIKRY
120
HIAKVYRRDN
130
PAMTRGRYRE
140
FYQCDFDIAG
150
QFDPMIPDAE
160
CLKIMCEILS
170
SLQIGDFLVK
180
VNDRRILDGL
190
FAICGVPDTK
200
FRTICSSVDK
210
LDKMSWEEVK
220
NEMVGEKGLA
230
PEVADRIGDY
240
VQQHGGVSLV
250
EQLLQDPKLS
260
QNKQALEGLG
270
DLKLLFEYLT
280
LFGVADKISF
290
DLSLARGLDY
300
YTGVIYEAVL
310
LQPPAQAGEE
320
PLGVGSVAAG
330
GRYDGLVGMF
340
DPKGRKVPCV
350
GLSIGVERIF
360
SIVEQRLEAL
370
EEKVRTTETQ
380
VLVASAQKKL
390
LEERLKLVSE
400
LWDAGIKAEL
410
LYKKNPKLLN
420
QLQYCEEAGI
430
PLVAIIGEQE
440
LKDGVVKLRS
450
VTSREEVDVR
460
REDLVEEIKR
RTSQPSCTC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004821 | histidine-tRNA ligase activity |
| Biological Process | GO:0006427 | histidyl-tRNA aminoacylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.