Search Results
Overview
| Uniprot ID | A0A8D1PS62 |
|---|---|
| Protein Name | Twinfilin-1 |
| Gene Name | TWF1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 144 | DVSLHGYKKYLLSQS |
| 38 | NGKYRLLKISIENEK |
| 45 | KISIENEKLVIGSCR |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles
Protein Sequence
10
LKHKLNILVY
20
LSLSFSPASE
30
DVKDIFARAR
40
NGKYRLLKIS
50
IENEKLVIGS
60
CRQPSDSWDK
70
DYDSFVLPML
80
EDKQPCYILF
90
RLDSQNAQGY
100
EWIFIAWSPD
110
HSHVRQKMLY
120
AATRATLKKE
130
FGGGHIKDEV
140
FGTVKEDVSL
150
HGYKKYLLSQ
160
SSPAPLTAAE
170
EELRQIKINE
180
NPEDHIGVQT
190
DVSVDTKHQT
200
LQGVAFPISR
210
EAFQALEKLN
220
NRQLNYVQLE
230
IDIKNEVIIL
240
ANTVNTELKD
250
LPKRIPKDSA
260
RYHFFLYKHS
270
HEGDYLDVFL
280
SVCSLGLSCS
290
FMRERMLYSS
300
CKSPLLEIVE
310
RQLQMDVIRK
320
IEIDNGDELT
330
ADFLYEEVHP
340
KQHAHKQSFA
350
KPKGPSGKRG
360
IRRLIRGPAE
TEATTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0004713 | protein tyrosine kinase activity |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0051016 | barbed-end actin filament capping |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0010591 | regulation of lamellipodium assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.