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Overview

Uniprot ID	A0A8D1QGF2
Protein Name	Prolyl endopeptidase
Gene Name	PREP
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
552	EYGETWHKGGILANK

Function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long

Protein Sequence

10 MCFLPGPHDP 20 LFLPFQVQSH 30 RRWKLGHLKP 40 SAFNAGARPL 50 LSPGIGRWGD 60 RIQDYHGHKV 70 CDPYAWLEDP 80 DSEQTKAFVE 90 AQNKITVPFL 100 EQCPIRGLYK 110 ERMTELYDYP 120 KYSCHFKKGK 130 RYFYFYNTGL 140 QNQRVLYVQD 150 SLEGEARVFL 160 DPNILSDDGT 170 VALRGYAFSE 180 DGEYFAYGLS 190 ASGSDWVTIK 200 FMKVDGAKEL 210 PDVLERVKFS 220 CMAWTHDGKG 230 MFYNAYPQQD 240 GKSDGTETST 250 NLHQKLYYHV 260 LGTDQSEDIL 270 CAEFPDEPKW 280 MGGAELSDDG 290 RYVLLSIREG 300 CDPVNRLWYC 310 DLQQESNGIT 320 GILKWVKLID 330 NFEGEYDYVT 340 NEGTVFTFKT 350 NRHSPNYRLI 360 NIDFTDPEES 370 KWKVLVPEHE 380 KDVLEWVACV 390 RSNFLVLCYL 400 HDVKNTLQLH 410 DLATGALLKI 420 FPLEVGSVVG 430 YSGQKKDTEI 440 FYQFTSFLSP 450 GIIYHCDLTK 460 EELEPRVFRE 470 VTVKGIDASD 480 YQTVQIFYPS 490 KDGTKIPMFI 500 VHKKGIKLDG 510 SHPAFLYGYG 520 GFNISITPNY 530 SVSRLIFVRH 540 MGGVLAVANI 550 RGGGEYGETW 560 HKGGILANKQ 570 NCFDDFQCAA 580 EYLIKEGYTS 590 PKRLTINGGS 600 NGGLLVATCA 610 NQRPDLFGCV 620 IAQVGVMDML 630 KFHKYTIGHA 640 WTTDYGCSDS 650 KQHFEWLIKY 660 SPLHNVKLPE 670 ADDIQYPSML 680 LLTADHDDRV 690 VPLHSLKFIA 700 TLQYIVGRSR 710 KQNNPLLIHV 720 DTKAGHGAGK 730 PTAKVIEEVS 740 DMFAFIARCL NIDWIP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0004252	serine-type endopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.