Search Results
Overview
| Uniprot ID | A0A8D1RD34 |
|---|---|
| Protein Name | Glutathione S-transferase LANCL1 |
| Gene Name | LANCL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | NKNFGVEKIPRSHIQ |
Function
Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione
Protein Sequence
10
MMAQRAFPNP
20
YADFNKSLAE
30
GYFDSAGRLT
40
PEFSQRVNNK
50
IRELLQQMER
60
GLKSADPRDG
70
TAYTGWAGIA
80
VLYLHLYDVF
90
GDPAYLQMAH
100
GYAKQSLNCL
110
TKRSITFLCG
120
DAGPLAVAAV
130
VHDKMNNEKQ
140
AEDCITRLIH
150
LNKIDPHAPN
160
EMLYGRMGYI
170
YALLFVNKNF
180
GVEKIPRSHI
190
QQICETVLTS
200
GENLARKRNF
210
TEKTPLMYEW
220
YQEYYVGAAH
230
GLAGIYYYLM
240
QPSLQVSHAK
250
LQSLVKPSVD
260
YVCQLKFPSG
270
NYPPCVDDTR
280
DLLVHWCHGS
290
PGVIYMLIQA
300
YKVFREERYL
310
NDAYQCADVI
320
WKYGLLKKGY
330
GLCHGTAGNA
340
YAFLTLFNLT
350
QDMKYLYRAC
360
KFAEWCLDYG
370
EHGCRTPDTP
380
FSLFEGMAGT
390
IYFLADLLVP
400
TKAKFPAFEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0005975 | carbohydrate metabolic process |
| Biological Process | GO:1990748 | cellular detoxification |
| Biological Process | GO:0031179 | peptide modification |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.