Search Results

Overview

Uniprot ID	A0A8D1RLG9
Protein Name	TRAF-type zinc finger domain-containing protein 1
Gene Name	TRAFD1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
118	CGRNVLVKDLKTHPE
69	LEKRQLKKHEETECP
95	ELSVLKLKDHEDYCG

Function

Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3

Protein Sequence

10 EAELLEVVKK 20 EIPVFNFTIH 30 EIHCQRNIGM 40 CAICKEPFPK 50 SDMETHMATE 60 HCQVTCKCNK 70 KLEKRQLKKH 80 EETECPLRLA 90 LCQHCDLELS 100 VLKLKDHEDY 110 CGARTELCGS 120 CGRNVLVKDL 130 KTHPEVCGRN 140 EEEKRDEVTM 150 LPNAYDDSWG 160 QDGIWIASQL 170 RQIEALDPPM 180 RLPRRPLRAF 190 ESDLFQSRTT 200 SQRSVTAQFP 210 IQNNLLEEQE 220 SQERNRRRQT 230 PKEGGEDSAN 240 LDFMLALSLQ 250 NEGQPPNMAE 260 QDLWRVVCEA 270 DQSHEGPSAL 280 NDIRGAADGT 290 MLPCEFCEEL 300 YPEELLIDHQ 310 TSCNPSCALP 320 PLGVGSTSPK 330 GMEDPDVIFQ 340 EIMQQAARNQ 350 LDSLGLRSSP 360 PVEDSIIIPC 370 EFCGVQLEEE 380 VLFHHQDQCD 390 QRPATANNHV 400 SEGIPRQDFQ 410 PRGTSPELPK 420 RRVRHQGDLS 430 SDYMDDIKQE 440 MAKGPTYPLP 450 LSRPINNMTA 460 TSNRLSVSTS 470 GPRPGCQPSP 480 PRTLKLNNLD 490 NQGIRGRNRN 500 SHNGALASEQ 510 IPAVHPARSL 520 YPENLVSAFP 530 RGPSGRYGAS 540 GRSEGGRNSR 550 VTPTTTSYCS 560 RTVKAKPPKQ 570 QGAGDAEEEE EEE

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0008270	zinc ion binding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.