Search Results
Overview
| Uniprot ID | A0A8D1S2M8 |
|---|---|
| Protein Name | PDZ and LIM domain protein 2 |
| Gene Name | PDLIM2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 337 | GDELYCEKHARQRYS |
Function
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity
Protein Sequence
10
MALTVDVVGP
20
APWGFRISGG
30
RDFHMPITVT
40
KVTERGKAEA
50
ADLRPGDIIV
60
AINGESAKGM
70
LHAEAQSKIR
80
QSPSPLRLQL
90
DRSRAASPGQ
100
TNGESSMEVL
110
ATRFQGSRRG
120
HTDSQSSLRS
130
SCSSQASLSP
140
RPSSPFSTLP
150
PTSPHTPAGE
160
VVTSHSLQSL
170
AHSPGPATAD
180
HLSYGGRPGS
190
RQAGDWAVLV
200
LPPQPSPGPR
210
SSSPRLSVAS
220
EGESHLLRED
230
SEVFKMLQEN
240
REARVAPRQS
250
SSFRLLQEAL
260
EAEERGGTPA
270
FLPSPLSPQS
280
SLPTSRVLAT
290
PPKLHTCEKC
300
STSIANQAVR
310
IQEGRYRHPG
320
CYTCADCGLN
330
LKMRGHFWVG
340
DELYCEKHAR
350
QRYSAPSTLN
SQA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0031941 | filamentous actin |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051371 | muscle alpha-actinin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0061061 | muscle structure development |
| Biological Process | GO:0030163 | protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.