Search Results
Overview
| Uniprot ID | A0A8D1S361 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | DCTN2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | DKFSQAAKVAELEKR |
| 206 | AKVAELEKRLTELEA |
| 274 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MEPPFFPLRK
20
EELTSTSVEH
30
IIVNPNAAYD
40
KFKDKRVGTK
50
GLDFSDRIGK
60
TKRTGYESGE
70
YEMLGEGLGV
80
KETPQQKYQR
90
LLHEVQELTT
100
EVEKIKMTVK
110
ESATEEKLTP
120
VVLAKQLAAL
130
KQQLVASHLE
140
KLLGPDAAIN
150
LTDPDGALAK
160
RLLLQLEATK
170
NTKGAGSGGK
180
TTSGSPPDSS
190
LVTYELHSRP
200
EQDKFSQAAK
210
VAELEKRLTE
220
LEATVRCDQD
230
AQNPLSAGLQ
240
GACLMETVEL
250
LQAKVSALDL
260
AVLDQVEARL
270
QSVLGKVNEI
280
AKHKASVEDA
290
DTQSKVHQLY
300
ETIQRWSPIA
310
STLPELVQRL
320
VTIKQLHEQA
330
MQFGQLLTHL
340
DTTQQMIACS
350
LKDNATLLTQ
360
VQTTMRENLS
370
TVEGNFANID
ERMKKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.