Overview
| Uniprot ID | A0A8D1TWE8 |
|---|
| Protein Name | Craniofacial development protein 1 |
|---|
| Gene Name | CFDP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 185 |
KEVDATSKEAKSFFK |
| 25 |
KTKGKKRKAQSIPAR |
Function
Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development
Protein Sequence
10
VSELVKEDEV
20
DGDEQTQKTK
30
GKKRKAQSIP
40
ARKRKQGGLS
50
FEEEEEENAN
60
EESGGSSSEE
70
EDSAAEQEKG
80
IGSEDARKKK
90
EDELWASFLN
100
DVGPKSKVPP
110
STHVKKGEET
120
EETSSSKLLV
130
KAEDLEKPKE
140
TEKVKITKVF
150
DFAGEEVRAV
160
PEAYGSSWAT
170
GQIRAVALFP
180
LRHNGVTKEV
190
DATSKEAKSF
200
FKQNEKEKPQ
210
ANVPSALPSL
220
AAGSGLKRSG
230
GMSSLLGKIG
240
AKKQKMSTLE
250
KSKLDWESFK
260
EEEGIGEELA
270
IHNRGKEGYI
280
ERKAFLDRVD
290
HRQFEIERDL
RLSKMKP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000776 |
kinetochore |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.