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Overview

Uniprot IDA0A8D1USE0
Protein NameIntegrin alpha-5
Gene NameITGA5
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
815 SSGPQILKCPEAECF
848 LHFRVWAKTFLQREH

Function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling

Protein Sequence

10 MSRGFRACKF 20 LGVPGLLPQG 30 SRILESSPSS 40 LEGDEPVEYK 50 SLQWFGATVR 60 AHGSSILACA 70 PLYSWRTEKE 80 PLNDPVGTCY 90 LSTDNFTRIL 100 EYAPCRSDFS 110 SAAGQGYCQG 120 GFSAEFTKTG 130 RVVLGGPGSY 140 FWQGQILSAT 150 QEQISESYYP 160 EYLINPVQGQ 170 LQTRQASSIY 180 DDSYLGYSVA 190 VGEFSGDDTE 200 DFVAGVPKGN 210 LTYGYVTILN 220 GSDIRSLYNF 230 SGEQMASYFG 240 YAVAATDING 250 DGLDDLLVGA 260 PLLMERTADG 270 RPQEVGRVYI 280 YLQSPAGMEP 290 APARTLTGHD 300 EFGRFGSSLT 310 PLGDLDQDGY 320 NDVAIGATFG 330 GENRQGAVFI 340 FPGGPEGLAS 350 KPSQVLQPLW 360 AAGHTPDFFG 370 SALRGGRDLD 380 GNGYPDLIVG 390 SFGVDKAVVY 400 RGRPIVSASA 410 SLSIFPAMFN 420 PEERSCNLEG 430 NPVACINLSF 440 CLNASGKHVP 450 DSIGFTVELQ 460 LDWQKQKGGV 470 RRVLFLASRQ 480 ATLTQTLLIQ 490 NGAREDCREM 500 KIYLRNESEF 510 RDKLSPIHIA 520 LNFSLDPQAP 530 VDSHGLRPVL 540 HYQSKSRIED 550 KAQILLDCGE 560 DNICVPDLQL 570 EVFGDQNHVY 580 LGDKNSLNLT 590 FHAQNVGEGG 600 AYEAELRVTA 610 PPEAEYSGLV 620 RHPGNFSSLS 630 CDYFAVNQSR 640 LLVCDLGNPM 650 KAGASLWSGL 660 RFTVPHLRDT 670 KKTIQFDFQI 680 LSKNLNNSQS 690 EVVSFRLSVE 700 AQAQVSLNGV 710 SKPEAVIFPV 720 SDWHPRDPPQ 730 EEEDVGPAVH 740 HVYELINLGP 750 SSISRGVLEL 760 SCPQALEGRQ 770 LLYVTRVTGL 780 SNCTTSHPLN 790 PQGLELDPES 800 PQHHRLQRRD 810 AASRSPASSG 820 PQILKCPEAE 830 CFRLRCELGP 840 LHRQESRSLQ 850 LHFRVWAKTF 860 LQREHQPFSL 870 QCEAVYQALK 880 MPYRILPRQL 890 PQKELQVATA 900 VQWIKAEGSH 910 GVPLWIIILA 920 ILVGLLLLGL 930 LIYILYKLGF 940 FKRSLPYGTA 950 MEKAQLKPPA TSDA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0008305 integrin complex
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005102 signaling receptor binding
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0045765 regulation of angiogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.