Search Results
Overview
| Uniprot ID | A0A8D1V1W8 |
|---|---|
| Protein Name | Cathepsin B |
| Gene Name | CTSB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | WPNCPTIKEIRDQGS |
| 255 | TPSYKEDKHFGCSSY |
| 89 | VDLSYVKKLCGTFLG |
| 99 | GTFLGGPKLPQRAAF |
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis
Protein Sequence
10
MTLEAWEKER
20
LRVAEFGESA
30
GCPGESRIHL
40
PKMWRLLATL
50
SCLVLLTSAR
60
ESLHFQPLSD
70
ELVNFINKQN
80
TTWTAGHNFY
90
NVDLSYVKKL
100
CGTFLGGPKL
110
PQRAAFAADM
120
ILPKSFDARE
130
QWPNCPTIKE
140
IRDQGSCGSC
150
WAFGAVEAIS
160
DRICIRSNGR
170
VNVEVSAEDM
180
LTCCGDECGD
190
GCNGGFPSGA
200
WNFWTKKGLV
210
SGGLYDSHVG
220
CRPYSIPPCE
230
HHVNGSRPPC
240
TGEGDTPKCS
250
KICEPGYTPS
260
YKEDKHFGCS
270
SYSISRNEKE
280
IMAEIYKNGP
290
VEGAFTVYSD
300
FLQYKSGVYQ
310
HVTGDLMGGH
320
AIRILGWGVE
330
NGTPYWLVGN
340
SWNTDWGDNG
350
FFKILRGQDH
360
CGIESEIVAG
IPCTPHF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0005764 | lysosome |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Biological Process | GO:0006508 | proteolysis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.