Overview
| Uniprot ID | A0A8D1V4X1 |
|---|
| Protein Name | Regulator of chromosome condensation |
|---|
| Gene Name | RCC1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 300 |
TSFKNSTKSWVRFSG |
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA
Protein Sequence
10
MPQDRKMPPK
20
RIAKRRSPPE
30
DALPKSKKVK
40
VSHRSHSTEP
50
GLVLTLGQGD
60
VGQLGLGENV
70
MERKKPALVP
80
IPEDIVQAEA
90
GGMHTVCLSK
100
SGQVYSFGCN
110
DEGALGRDTS
120
VEGSEMVPGK
130
VELQEKVVQV
140
SAGDSHTAAL
150
TEDGRVFLWG
160
SFRDNNGVIG
170
LLEPMKKSMV
180
PVQVQLSMPV
190
VKVASGNDHL
200
VMLTADGELY
210
TLGSGEQGQL
220
GRVPELFANR
230
GGRQGLERLL
240
VPKCVMLKSR
250
GSRGHVRFQD
260
AFCGAYFTFA
270
ISSEGHVYGF
280
GLSNYHQLGT
290
PGTESCFVPQ
300
NLTSFKNSTK
310
SWVRFSGGQH
320
HTVCMDSEGR
330
AYSLGRAEYG
340
RLGLGEGAEE
350
KSVPTLISRL
360
PAVSSVACGA
370
SVGYAVTKDG
380
RVFAWGMGTN
390
YQLGTGQEED
400
AWSPVEMTGK
410
QLENRMVLSV
420
SSGGQHTVLL
VKDKEQS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Biological Process |
GO:0051301 |
cell division |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.