Search Results
Overview
| Uniprot ID | A0A8D1VEE4 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase |
| Gene Name | ITCH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 785 | PQKFCIEKVGKENWL |
Function
No function data available.
Protein Sequence
10
MTDSRSQLGS
20
MGSLTMKSQL
30
QITVISAKLK
40
ENKKNWFGPS
50
PYVEVTVDGQ
60
SKKTEKCNNT
70
NSPKWKQPLT
80
VIVTPVSKLH
90
FRVWSHQTLK
100
SDVLLGTAAL
110
DIYETLKSNN
120
MKLEEVVVTL
130
QLVGDKEPTE
140
TIGDLSVCLD
150
GLQLESEVVT
160
NGETSCSESA
170
SQNDDGSRPK
180
DETRVNTNGS
190
DDLEDAGSSD
200
SRRVNGNNSP
210
SLSNGGFKPS
220
RPPRPSRPPP
230
PTPRRPASVN
240
GSPSATSESD
250
GSSTGSLPPT
260
NTNSNTSEGA
270
TSGLIIPLTI
280
SGGSGPRPLN
290
PVPQAPLPPG
300
WERRVDNMGR
310
IYYVDHFTRT
320
TTWQRPTLES
330
VRNYEQWQLQ
340
RSQLQGAMQQ
350
FNQRFIYGNQ
360
DLFATSQNKE
370
FDPLGPLPPG
380
WEKRTDSNGR
390
VYFVNHNTRI
400
TQWEDPRNQG
410
QLNEKPLPEG
420
WEMRFTVDGI
430
PYFVDHNRRT
440
TTYIDPRTGK
450
SALDNGPQIA
460
YVRDFKAKVQ
470
YFRFWCQQLA
480
MPQHIKITVT
490
RKTLFEDSFQ
500
QIMSFSPQDL
510
RRRLWVIFPG
520
EEGLDYGGVA
530
REWFFLLSHE
540
VLNPMYCLFE
550
YAGKDNYCLQ
560
INPASYINPD
570
HLKYFRFIGR
580
FIAMALFHGK
590
FIDTGFSLPF
600
YKRILNKPVG
610
LKDLESIDPE
620
FYNSLIWVKE
630
NNIEECGLEM
640
YFSVDKEILG
650
EIKSHDLKPN
660
GGNILVTEEN
670
KEEYIRMVAE
680
WRLSRGVEEQ
690
TQAFFEGFNE
700
ILPQQYLQYF
710
DAKELEVLLC
720
GMQEIDLNDW
730
QRHAIYRHYT
740
RTSKQIMWFW
750
QFVKEIDNEK
760
RMRLLQFVTG
770
TCRLPVGGFA
780
DLMGSNGPQK
790
FCIEKVGKEN
800
WLPRSHTCFN
810
RLDLPPYKSY
820
EQLKEKLLFA
830
IEETEGFGQE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:1990763 | arrestin family protein binding |
| Molecular Function | GO:0045236 | CXCR chemokine receptor binding |
| Molecular Function | GO:0016874 | ligase activity |
| Molecular Function | GO:0043021 | ribonucleoprotein complex binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Molecular Function | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0039532 | negative regulation of cytoplasmic pattern recognition receptor signaling pathway |
| Biological Process | GO:0050687 | negative regulation of defense response to virus |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:2000646 | positive regulation of receptor catabolic process |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0051865 | protein autoubiquitination |
| Biological Process | GO:0141198 | protein branched polyubiquitination |
| Biological Process | GO:0035519 | protein K29-linked ubiquitination |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0006513 | protein monoubiquitination |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0090085 | regulation of protein deubiquitination |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.