Overview
| Uniprot ID | A0A8D1X9E3 |
|---|
| Protein Name | Proteasome activator complex subunit 3 |
|---|
| Gene Name | PSME3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 111 |
EIRLLIEKCNTVKMW |
| 12 |
LKVDQEVKLKVDSFR |
| 14 |
VDQEVKLKVDSFRER |
| 174 |
KLVSKIAKYPHVEDY |
Function
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition
Protein Sequence
10
MASLLKVDQE
20
VKLKVDSFRE
30
RITSEEPILN
40
IHDLTQIHSD
50
MNLPVPDPIL
60
LTNSHDGLDG
70
PTYKKRRLDE
80
CEEAFQGTKV
90
FVMPNGMLKS
100
NQQLVDIIEK
110
VKPEIRLLIE
120
KCNTVKMWVQ
130
LLIPRIEDGN
140
NFGVSIQEET
150
VAELRTVESE
160
AASYLDQISR
170
YYITRAKLVS
180
KIAKYPHVED
190
YRRTVTEIDE
200
KEYISLRLII
210
SELRNQYVTL
220
HDMILKNIEK
230
IKRPRSSNAE
TLY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008537 |
proteasome activator complex |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.