Overview
| Uniprot ID | A0A8D1YR24 |
|---|
| Protein Name | 26S proteasome regulatory subunit 6A |
|---|
| Gene Name | PSMC3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 234 |
DSEIKIMKSEVLRVT |
| 303 |
KGKCAVIKTSTRQTY |
| 351 |
TEYDSRVKAMEVDER |
| 389 |
LPMNHKEKFENLGIQ |
| 423 |
RACAAQTKATFLKLA |
| 454 |
RDAFALAKEKAPSII |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides
Protein Sequence
10
MGQDQTKQQI
20
EKGLQLYQSN
30
QTEKALQVWM
40
KVLEKSSDLV
50
GRFRVLGCLV
60
TAHSEMGRYK
70
EMLKFAVVQI
80
DTARELEDAN
90
FLLESYLNLA
100
RSNEKLCEFH
110
KTISYCKTCL
120
GLPGTRAGAQ
130
LGGQVSLSMG
140
NAFLGLSLFQ
150
KALESFEKAL
160
RYAHNNDDAM
170
LECRVCCSLG
180
SFYAQVKEMN
190
LLPQLESPVT
200
RQEKMATVWD
210
EAEQDGIGEE
220
VLKMSTEEIV
230
QRTRLLDSEI
240
KIMKSEVLRV
250
THELQAMKDK
260
IKENSEKIKV
270
NKTLPYLVSN
280
VIELLDVDPN
290
DQEEDGANID
300
LDSQRKGKCA
310
VIKTSTRQTY
320
FLPVIGLVDA
330
EKLKPGDLVG
340
VNKDSYLILE
350
TLPTEYDSRV
360
KAMEVDERPT
370
EQYSDIGGLD
380
KQIQELVEAI
390
VLPMNHKEKF
400
ENLGIQPPKG
410
VLMYGPPGTG
420
KTLLARACAA
430
QTKATFLKLA
440
GPQLVQMFIG
450
DGAKLVRDAF
460
ALAKEKAPSI
470
IFIDELDAIG
480
TKRFDSEKAG
490
DREVQRTMLE
500
LLNQLDGFQP
510
NTQVKVIAAT
520
NRVDILDPAL
530
LRSGRLDRKI
540
EFPMPNEEAR
550
ARIMQIHSRK
560
MNVSPDVNYE
570
ELARCTDDFN
580
GAQCKAVCVE
590
AGMIALRRGA
600
TELTHEDYME
610
GILEVQAKKK
ANLQYYA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0033130 |
acetylcholine receptor binding |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0043495 |
protein-membrane adaptor activity |
| Biological Process |
GO:0007268 |
chemical synaptic transmission |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.