Search Results
Overview
| Uniprot ID | A0A8D2AAA4 |
|---|---|
| Protein Name | Histidine--tRNA ligase, cytoplasmic |
| Gene Name | HARS1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | LKETLTGKYGEDSKL |
| 154 | IKRYHIAKVYRRDNP |
| 418 | VLVASAQKKLLEERL |
| 42 | VAKLLKLKAQLGPDE |
Function
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance
Protein Sequence
10
MAGRETLEEL
20
VRLQGERVRG
30
LKQQKASTEQ
40
IEEEVAKLLK
50
LKAQLGPDEG
60
KHKFVLKTPK
70
GTRDYSPRQM
80
AVREKVFDVI
90
IGCFKRHGAE
100
VIDTPVFELK
110
ETLTGKYGED
120
SKLIYDLKDQ
130
GGELLSLRYD
140
LTVPFARYLA
150
MNKLTNIKRY
160
HIAKVYRRDN
170
PAMTRGRYRE
180
FYQCDFDIAG
190
QFDPMIPDAE
200
CLKIMCEILS
210
SLQIGDFLVK
220
VNDRRILDGL
230
FAICGVPDTK
240
FRTICSSVDK
250
LDKMSWEEVK
260
NEMVGEKGLA
270
PEVADRIGDY
280
VQQHGGVSLV
290
EQLLQDPKLS
300
QNKQALEGLG
310
DLKLLFEYLT
320
LFGVADKISF
330
DLSLARGLDY
340
YTGVIYEAVL
350
LQPPAQAGEE
360
PLGVGSVAAG
370
GRYDGLVGMF
380
DPKGRKVPCV
390
GLSIGVERIF
400
SIVEQRLEAL
410
EEKVRTTETQ
420
VLVASAQKKL
430
LEERLKLVSE
440
LWDAGIKAEL
450
LYKKNPKLLN
460
QLQYCEEAGI
470
PLVAIIGEQE
480
LKDGVVKLRS
490
VTSREEVDVR
500
REDLVEEIKR
RTSQPSCTC
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004821 | histidine-tRNA ligase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0006427 | histidyl-tRNA aminoacylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.