Overview
| Uniprot ID | A0A8D2BTD3 |
|---|
| Protein Name | Proteasome subunit alpha type-6 |
|---|
| Gene Name | PSMA6 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 165 |
KATAAGVKQTESTSF |
| 39 |
TSVAVRGKDCAVIVT |
| 48 |
CAVIVTQKKVPDKLL |
| 96 |
RYEAANWKYKYGYEI |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MHRCHTLSYT
20
EAHSFKVVTE
30
YAFKAINQGG
40
LTSVAVRGKD
50
CAVIVTQKKV
60
PDKLLDSSTV
70
THLFKITENI
80
GCVMTGMTAD
90
SRSQVQRARY
100
EAANWKYKYG
110
YEIPVDMLCK
120
RIADISQVYT
130
QNAEMRPLGC
140
CMILIGIDEE
150
QGPQVYKCDP
160
AGYYCGFKAT
170
AAGVKQTEST
180
SFLEKKVKKK
190
FDWTFEQTVE
200
TAITCLSTVL
210
SIDFKPSEIE
220
VGVVTVENPK
230
FRILTEAEID
240
AHLVALAERD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0051603 |
proteolysis involved in protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.