Search Results
Overview
| Uniprot ID | A0A8I5XVY2 |
|---|---|
| Protein Name | Inosine triphosphate pyrophosphatase |
| Gene Name | Itpa |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 209 | AEMPKAEKNTISHRF |
Function
Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions
Protein Sequence
10
MGVCSGFHLR
20
VEDSRGLSRA
30
SGFRQGRKPS
40
YLLPPPAGSA
50
FPAKRFWAFW
60
TVTRACNGRV
70
FGWEEDSVCD
80
GKRKEAGGVP
90
EYQGEPDEIS
100
IQKCQEAARQ
110
VQGPVLVEDT
120
CLCFNALGGL
130
PGPYIKWFLQ
140
KLKPEGLYQL
150
LAGFEDKSAY
160
ALCTFALSTG
170
DPSQPVLLFR
180
GKTPGQIVMP
190
RGSRDFGWDP
200
CFQPDGYEQT
210
YAEMPKAEKN
220
TISHRFRALF
230
KLQEYFGVTD
GAGDH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0035870 | dITP diphosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036220 | ITP diphosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0036222 | XTP diphosphatase activity |
| Biological Process | GO:0009204 | deoxyribonucleoside triphosphate catabolic process |
| Biological Process | GO:0009117 | nucleotide metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.