Search Results
Overview
| Uniprot ID | A0A8I5Y4S4 |
|---|---|
| Protein Name | Protein enabled homolog |
| Gene Name | Enah |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 675 | RRRRIAEKGSTIETE |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation
Protein Sequence
10
MSEQSICQAR
20
AAVMVYDDAN
30
KKWVPAGGST
40
GFSRVHIYHH
50
TGNNTFRVVG
60
RKIQDHQVVI
70
NCAIPKGLKY
80
NQATQTFHQW
90
RDARQVYGLN
100
FGSKEDANVF
110
ASAMMHALEV
120
LNSQEAGPTL
130
PRQNSQLPAQ
140
VQNGPSQEEM
150
EIQRRQLQEQ
160
QRQKELERER
170
MERERLERER
180
LERERLERER
190
LEQEQLERQR
200
QEREHVERLE
210
RERLERLERE
220
RQDRERERER
230
LEQLEREQVE
240
WERERRMSNA
250
APSSDSSLYS
260
APLPEYSSCQ
270
PPSAPPPSYA
280
KVISAPVSDA
290
APDYAVVTAL
300
PPTSTPPTPP
310
LRHSATRFAT
320
SLGSAFHPVL
330
PHYATVPRPL
340
NRNSRPSSPV
350
NTPSSQPPAA
360
KSCAWPTSNF
370
SPLPPSPPIM
380
ISSPPGKATG
390
PRPVLPVCVS
400
SPVPQMPPSP
410
TAPNGSLDSV
420
TYPVSPPPTS
430
GPAAPPPPPP
440
PPPPPPPPPP
450
PPPLPPLASL
460
SHCGSQASPP
470
PGTPLASTPS
480
SKPSVLPSPS
490
AAAPASVETP
500
LNPELGDSSA
510
SEPGLQAASQ
520
PAETPAPQGH
530
VLGPPAPPPP
540
PPLPSGPAYA
550
SALPPPPGPP
560
PPPPLPSAGP
570
PPPPPPPPPL
580
PNQVPPPPPP
590
PPAPPLPASG
600
IFSGSMSEDN
610
RPLTGLAAAI
620
AGAKLRKVSR
630
VEDGSFPSGG
640
NTVSVNLASS
650
KTDSGRGNGP
660
LPLGGSGLME
670
EMSALLARRR
680
RIAEKGSTIE
690
TEQKEDRSED
700
AEPVTSKAAS
710
TSTPEPTRKP
720
WERTNTMNGS
730
KSPVISRRDS
740
PRKNQIVFDN
750
RSYDSLHRPK
760
STPSSQPSAN
770
GVQTEGLDYD
780
RLKQDILDEM
790
RKELAKLKEE
800
LIDAIRQELS
KSNTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005522 | profilin binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0008154 | actin polymerization or depolymerization |
| Biological Process | GO:0070358 | actin polymerization-dependent cell motility |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0001843 | neural tube closure |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.