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Overview

Uniprot IDA0A8I5Y5E9
Protein NameNADH-cytochrome b5 reductase
Gene NameCyb5r3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
164 KFAIRADKKSNPVVR

Function

Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor

Protein Sequence

10 MGSALSLQLS 20 RVVLSPVWFV 30 YSLFMKLFQR 40 SSPAITLENP 50 DIKYPLRLID 60 KEIISHDTRR 70 FRFALPSPQH 80 ILGLPIGQHI 90 YLSTRIDGNL 100 VIRPYTPVSS 110 DDDKGFVDLV 120 VKVYFKDTHP 130 KFPAGGKMSQ 140 YLENMNIGDT 150 IEFRGPNGLL 160 VYQGKGKFAI 170 RADKKSNPVV 180 RTVKSVGMIA 190 GGTGRSVARP 200 GCPTCITPML 210 QVIRAVLKDP 220 NDHTVCYLLF 230 ANQSEKDILL 240 RPELEELRNE 250 HSSRFKLWYT 260 VDKAPDAWDY 270 SQGFVNEEMI 280 RDHLPPPGEE 290 TLILMCGPPP 300 MIQFACLPNL 310 ERVGHPKERC FTF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:1903958 nitric-oxide synthase complex
Molecular Function GO:0090524 cytochrome-b5 reductase activity, acting on NADH
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0050421 nitrite reductase (NO-forming) activity
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0006809 nitric oxide biosynthetic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.