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Overview

Uniprot IDA0A8I5Y747
Protein NameNucleolin
Gene NameNcl
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
102 KKAVTPAKVVPTPGK
109 KVVPTPGKKGAAQAK
116 KKGAAQAKALVPTPG
124 ALVPTPGKKGAVTPA
232 KGKKTPAKVVPVKAK
472 SLYYTGEKGQRQERT
481 QRQERTGKNSTWSGE
576 NARSQPSKTLFVKGL
63 ATTTPAKKVVVSQTK
71 VVVSQTKKAAVPTPA
79 AAVPTPAKKAAVTPG
80 AVPTPAKKAAVTPGK

Function

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats

Protein Sequence

10 MVKLAKAGKT 20 HGESKKMAPP 30 PKEVEEDSED 40 EEMSEDEDDS 50 SGEEEVVIPQ 60 KKGKKATTTP 70 AKKVVVSQTK 80 KAAVPTPAKK 90 AAVTPGKKAA 100 ATPAKKAVTP 110 AKVVPTPGKK 120 GAAQAKALVP 130 TPGKKGAVTP 140 AKGAKNGKNA 150 KKEDSDEDED 160 EEDEDDSDED 170 EDEEDEFEPP 180 VVKGVKPAKA 190 APAAPASEDE 200 DEEDDDDEED 210 DDDDDEEEEE 220 EDDSEEEVME 230 ITPAKGKKTP 240 AKVVPVKAKS 250 VAEEEEDDED 260 DEDEEEDEDE 270 EDEEDDEDED 280 EEEEEEPVKA 290 APGKRKKEMT 300 KQKEAPEAKK 310 QKIEGSEPTT 320 PFNLFIGNLN 330 PNKSVAELKV 340 AISELFAKND 350 LAAVDVRTGT 360 NRKFGYVDFE 370 SAEDLEKALE 380 LTGLKVFGNE 390 IKLEKPKGRD 400 SKKVRAARTL 410 LAKNLSFNIT 420 EDELKEVFED 430 AVEIRLVSQD 440 GRSKGIAYIE 450 FKSEADAEKN 460 LEEKQGAEID 470 GRSVSLYYTG 480 EKGQRQERTG 490 KNSTWSGESK 500 TLVLSNLSYS 510 ATEETLQEVF 520 EKATFIKVPQ 530 NPHGKSKGYA 540 FIEFASFEDA 550 KEALNSCNKM 560 EIEGRTIRLE 570 LQGPRGSPNA 580 RSQPSKTLFV 590 KGLSEDTTEE 600 TLKESFEGSV 610 RARIVTDRET 620 GSSKGFGFVD 630 FNSEEDAKAA 640 KEAMEDGEID 650 GNKVTLDWAK 660 PKGEGGFGGR 670 GGGRGGRGGF 680 GGRGRGGFGG 690 RGGFRGGRGG 700 GGDFKPQGKK TKFE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003723 RNA binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.