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Overview

Uniprot IDA0A8I5Y7A1
Protein NameT-complex protein 1 subunit gamma
Gene NameCct3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
222 LRGVMINKDVTHPRM
370 ITDCKDPKACTILLR
381 ILLRGASKEILSEVE

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia

Protein Sequence

10 MMGHRPVLVL 20 SQNTKRESGR 30 KVQSGNINAA 40 KTIADIIRTC 50 LGPKSMMKML 60 LDPMGGIVMT 70 NDGNAILREI 80 QVQHPAAKSM 90 IEISRTQDEE 100 VGDGTTSVII 110 LAGEMLSVAE 120 HFLEQQMHPT 130 VVISAYRMAL 140 DDMVSTLKKI 150 STPVDVNNRD 160 MMLNIINSSI 170 TTKVISRWSS 180 LACNIALDAV 190 KTVQFEENGR 200 KEIDIKKYAR 210 VEKIPGGIIE 220 DSCVLRGVMI 230 NKDVTHPRMR 240 RYIKNPRIVL 250 LDSSLEYKKG 260 ESQTDIEITR 270 EEDFTRILQM 280 EEEYIQQLCE 290 DIIQLKPDVV 300 ITEKGISDLA 310 QHYLMRANVT 320 AIRRVRKTDN 330 NRIARACGAR 340 IVSRPEELRE 350 DDVGTGAGLL 360 EIKKIGDEYF 370 TFITDCKDPK 380 ACTILLRGAS 390 KEILSEVERN 400 LQDAMQVCRN 410 VLLDPQLVPG 420 GGASEMAVAH 430 ALTEKSKAMT 440 GVEQWPYRAV 450 AQALEVIPRT 460 LIQNCGASTI 470 RLLTSLRAKH 480 TQENCETWGV 490 NGETGTLVDM 500 KELGIWEPLA 510 VKLQTYKTAV 520 EVRRHTSFLS R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005832 chaperonin-containing T-complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0051082 unfolded protein binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.