Search Results

Overview

Uniprot IDA0A8I5Y8E5
Protein NameProtein phosphatase 1 regulatory subunit
Gene NamePpp1r12a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
320 PQKTFKNKETLIIEP
856 AYSRGLTKDNEREGE

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity

Protein Sequence

10 MKMADAKQKR 20 NEQLKRWIGS 30 ETDLEPPVVK 40 RQKTKVKFDD 50 GAVFLAACSS 60 GDTDEVLKLL 70 HRGADINYAN 80 VDGLTALHQA 90 CIDDNVDMVK 100 FLVENGANIN 110 QPDNEGWIPL 120 HAAASCGYLD 130 IAEFLIGQGA 140 HVGAVNSEGD 150 TPLDIAEEEA 160 MEELLQNEVN 170 RQGVDIEAAR 180 KEEERIMLRD 190 ARQWLNSGHI 200 SDVRHAKSGG 210 TALHVAAAKG 220 YTEVLKLLIQ 230 AGYDVNIKDY 240 DGWTPLHAAA 250 HWGKEEACRI 260 LVDNLCDMET 270 VNKVGQTAFD 280 VADEDILGYL 290 EELQKKQNLL 300 HSEKRDKKSP 310 LIESTANMEN 320 NQPQKTFKNK 330 ETLIIEPEKN 340 ASRIESLEQE 350 KADEEEEGKK 360 DESSCSSEED 370 EEDDSESEAE 380 TDKTKPMASV 390 TNAHTASTQA 400 APAAVTTPTL 410 SSNQGTPTSP 420 VKKFDFIASL 430 MPVESVDPAS 440 WRQGLRKTGI 450 VLVPSKGEKS 460 MFPTSTTKIS 470 PKEEERKDES 480 PASWRLGLRK 490 TGSYGALAEI 500 TASKEAQKEK 510 DTAGVIRSAS 520 SPRLSSSLDN 530 KEKEKDNKGT 540 RLAYVAPTIP 550 RRLGSTSDIE 560 EKENRESSNL 570 RTSSSYTRRK 580 WEDDLKKNSS 590 INEGSTYHRS 600 CSFGRRQDDL 610 ISCSVPSTTS 620 TPTVTSAAGL 630 QKSFLSSTST 640 TAKTPPGSSP 650 AGTQSSTSNR 660 LWAEDSTEKE 670 KDSAPTAATI 680 PVAPTVVSAA 690 ASSTTALTTT 700 TAGTLSSTSE 710 VRERRRSYLT 720 PVRDEESESQ 730 RKARSRQARQ 740 SRRSTQGVTL 750 TDLQEAEKTI 760 GRSRSTRTRE 770 QENEEKDKEE 780 KEKQDKEKQE 790 EKKESEVSRE 800 DEYKQKYSRT 810 YDETYARYRP 820 VSTSSSSTPS 830 SSSLSTLGSS 840 LYASSQLNRP 850 NSLVGITSAY 860 SRGLTKDNER 870 EGEKKEEEKE 880 GEDKSQPKSI 890 RERRRPREKR 900 RSTGVSFWTQ 910 DSDENEQERQ 920 SDTEDGSSKR 930 DTQTDSVSRY 940 DSSSTSSSDR 950 YDSLLGRSAS 960 YSYLEERKPY 970 GSRLEKDDST 980 DFKKLYEQIL 990 AENEKLKAQL 1000 HDTNMELTDL 1010 KLQLEKATQR 1020 QERFADRSLL 1030 EMEKRERRAL 1040 ERRISEMEEE 1050 LKMLPDLKAD 1060 NQRLKDENGA 1070 LIRVISKLSK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031672 A band
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0072357 PTW/PP1 phosphatase complex
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0071889 14-3-3 protein binding
Molecular Function GO:0004857 enzyme inhibitor activity
Molecular Function GO:0019208 phosphatase regulator activity
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0007165 signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.