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Overview

Uniprot ID	A0A8I5Y9U9
Protein Name	Clathrin heavy chain
Gene Name	Cltc
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
683	ACKTGQIKEVERICR
797	VEKRNRLKLLLPWLE

Function

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating

Protein Sequence

10 MHYGDPAKLK 20 YNFFSKRSFH 30 KIKLAGKTLQ 40 IFNIEMKSKM 50 KAHTMTDDVT 60 FWKWISLNTV 70 ALVTDNAVYH 80 WSMEGESQPV 90 KMFDRHSSLA 100 GCQIINYRTD 110 AKQKWLLLTG 120 ISAQQNRVVG 130 AMQLYSVDRK 140 VSQPIEGHAA 150 SFAQFKMEGN 160 AEESTLFCFA 170 VRGQAGGKLH 180 IIEVGTPPTG 190 NQPFPKKAVD 200 VFFPPEAQND 210 FPVAMQISEK 220 HDVVFLITKY 230 GYIHLYDLET 240 GTCIYMNRIS 250 GETIFVTAPH 260 EATAGIIGVN 270 RKGQVLSVCV 280 EEENIIPYIT 290 NVLQNPDLAL 300 RMAVRNNLAG 310 AEELFARKFN 320 ALFAQGNYSE 330 AAKVAANAPK 340 GILRTPDTIR 350 RFQSVPAQPG 360 QTSPLLQYFG 370 ILLDQGQLNK 380 YESLELCRPV 390 LQQGRKQLLE 400 KWLKEDKLEC 410 SEELGDLVKS 420 VDPTLALSVY 430 LRANVPNKVI 440 QCFAETGQVQ 450 KIVLYAKKVG 460 YTPDWIFLLR 470 NVMRISPDQG 480 QQFAQMLVQD 490 EEPLADITQI 500 VDVFMEYNLI 510 QQCTAFLLDA 520 LKNNRPSEGP 530 LQTRLLEMNL 540 MHAPQVADAI 550 LGNQMFTHYD 560 RAHIAQLCEK 570 AGLLQRALEH 580 FTDLYDIKRA 590 VVHTHLLNPE 600 WLVNYFGSLS 610 VEDSLECLRA 620 MLSANIRQNL 630 QICVQVASKY 640 HEQLSTQSLI 650 ELFESFKSFE 660 GLFYFLGSIV 670 NFSQDPDVHF 680 KYIQAACKTG 690 QIKEVERICR 700 ESNCYDPERV 710 KNFLKEAKLT 720 DQLPLIIVCD 730 RFDFVHDLVL 740 YLYRNSLQKY 750 IEIYVQKVNP 760 SRLPVVIGGL 770 LDVDCSEDVI 780 KNLILVVRGQ 790 FSTDELVAEV 800 EKRNRLKLLL 810 PWLEARIHEG 820 CEEPATHNAL 830 AKIYIDSNNN 840 PERFLRENPY 850 YDSRVVGKYC 860 EKRDPHLACV 870 AYERGQCDLE 880 LINVCNENSL 890 FKSLSRYLVR 900 RKDPELWGSV 910 LLESNPYRRP 920 LIDQVVQTAL 930 SETQDPEEVS 940 VTVKAFMTAD 950 LPNELIELLE 960 KIVLDNSVFS 970 EHRNLQNLLI 980 LTAIKADRTR 990 VMEYINRLDN 1000 YDAPDIANIA 1010 ISNELFEEAF 1020 AIFRKFDVNT 1030 SAVQVLIEHI 1040 GNLDRAYEFA 1050 ERCNEPAVWS 1060 QLAKAQLQKG 1070 MVKEAIDSYI 1080 KADDPSSYME 1090 VVQAANTSGN 1100 WEELVKYLQM 1110 ARKKARESYV 1120 ETELIFALAK 1130 TNRLAELEEF 1140 INGPNNAHIQ 1150 QVGDRCYDEK 1160 MYDAAKLLYN 1170 NVSNFGRLAS 1180 TLVHLGEYQA 1190 AVDGARKANS 1200 TRTWKEVCFA 1210 CVDGKEFRLA 1220 QMCGLHIVVH 1230 ADELEELINY 1240 YQDRGYFEEL 1250 ITMLEAALGL 1260 ERAHMGMFTE 1270 LAILYSKFKP 1280 QKMREHLELF 1290 WSRVNIPKVL 1300 RAAEQAHLWA 1310 ELVFLYDKYE 1320 EYDNAIITMM 1330 NHPTDAWKEG 1340 QFKDIITKVA 1350 NVELYYKAIQ 1360 FYLEFKPLLL 1370 NDLLMVLSPR 1380 LDHTRAVNYF 1390 SKVKQLPLVK 1400 PYLRSVQNHN 1410 NKSVNESLNN 1420 LFITEEDYQA 1430 LRTSIDAYDN 1440 FDNISLAQRL 1450 EKHELIEFRR 1460 IAAYLFKGNN 1470 RWKQSVELCK 1480 KDSLYKDAMQ 1490 YASESKDTEL 1500 AEELLQWFLQ 1510 EEKRECFGAC 1520 LFTCYDLLRP 1530 DVVLETAWRH 1540 NIMDFAMPYF 1550 IQVMKEYLTK 1560 VDKLDASESL 1570 RKEEEQATET 1580 QPIVYGQPQL 1590 MLTAGPSVAV 1600 PPQAPFGYGY 1610 TAPPYGQPQP GFGYSM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030132	clathrin coat of coated pit
Cellular Component	GO:0030130	clathrin coat of trans-Golgi network vesicle
Cellular Component	GO:0071439	clathrin complex
Molecular Function	GO:0032051	clathrin light chain binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.