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Overview

Uniprot ID	A0A8I5Y9W6
Protein Name	Electron transfer flavoprotein-ubiquinone oxidoreductase
Gene Name	Etfdh
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
222	TNDVGIQKDGAPKTT
283	ELWVIDEKKWKPGRV

Function

Accepts electrons from ETF and reduces ubiquinone

Protein Sequence

10 MLVRLTKLSC 20 PAYQWFHALK 30 IKKCLPLCAP 40 RCSSTSAVPQ 50 ITTHYTIHPR 60 EKDKRWEGVN 70 MERFAEEADV 80 VIVGAGPAGL 90 SAAIRLKQLA 100 AEQEKDIRVC 110 LVEKAAQIGA 120 HTLSGACLDP 130 AAFKELFPDW 140 KEKGAPLNTP 150 VTEDRFAILT 160 EKHRIPVPIL 170 PGLPMNNHGN 180 YIVRLGHLVS 190 WMGEQAEALG 200 VEVYPGYAAA 210 EVLYHEDGSV 220 KGIATNDVGI 230 QKDGAPKTTF 240 ERGLELHAKV 250 TIFAEGCHGH 260 LAKQLYKKFD 270 LRASCDAQTY 280 GIGLKELWVI 290 DEKKWKPGRV 300 DHTVGWPLDR 310 HTYGGSFLYH 320 LNEGEPLVAV 330 GFVVGLDYQN 340 PYLSPFREFQ 350 RWKHHPSIRP 360 TLEGGKRIAY 370 GARALNEGGL 380 QSIPKLTFPG 390 GLLIGCSPGF 400 MNVPKIKGTH 410 TAMKSGSLAA 420 EAIFKQLTSE 430 NLQSKTAGLH 440 VTEYEDNLKQ 450 SWVWKELHAV 460 RNIRPSCHGI 470 LGVYGGMIYT 480 GIFYWILRGM 490 EPWTLKHKGS 500 DSEQLKPAKD 510 CTPIEYPKPD 520 GQISFDLLSS 530 VALSGTNHEH 540 DQPAHLTLKD 550 DSIPVNRNLS 560 IYDGPEQRFC 570 PAVKWFEEES

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding
Molecular Function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
Molecular Function	GO:0046872	metal ion binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.