Search Results
Overview
| Uniprot ID | A0A8I5YBU1 |
|---|---|
| Protein Name | Rab GDP dissociation inhibitor |
| Gene Name | Gdi2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | TFEGVDPKKTSMRDV |
| 174 | CETINRIKLYSESLA |
| 233 | NGKVVGVKSEGEIAR |
| 76 | IEGSFVYKGGKIYKV |
Function
GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A
Protein Sequence
10
MNEEYDVIVL
20
GTGLTLYKRF
30
KLPGQPPASM
40
GRGRDWNVDL
50
IPKFLMANGQ
60
LVKMLLFTEV
70
TRYMDFKVIE
80
GSFVYKGGKI
90
YKVPSTEAEA
100
LASSLMGLFE
110
KRRFRKFLVY
120
VANFDEKDPR
130
TFEGVDPKKT
140
SMRDVYKKFD
150
LGQDVIDFTG
160
HSLALYRTDD
170
YLDQPCCETI
180
NRIKLYSESL
190
ARYGKSPYLY
200
PLYGLGELPQ
210
GFARLSAIYG
220
GTYMLNKPIE
230
EIIVQNGKVV
240
GVKSEGEIAR
250
CKQLICDPSY
260
VKDRVEKVGQ
270
VIRVICILSH
280
PIKNTNDANS
290
CQIIIPQNQV
300
NRKSDIYVCM
310
ISFAHNVAAQ
320
GKYIAIVSTT
330
VETKEPEKEI
340
RPALELLEPI
350
EQKFVSISDL
360
FVPKDLGTDS
370
QIFISRAYDA
380
TTHFETTCDD
390
IKDIYKRMTG
400
SEFDFEEMKR
KKNDIYGED
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0005093 | Rab GDP-dissociation inhibitor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.