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Overview

Uniprot IDA0A8I5YC72
Protein NameMethylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Gene NameAldh6a1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
101 QLIKENLKEIARLIT
31 VKLFIDGKFVESKSD
60 GRVPQSTKAEMEAAV

Function

Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine

Protein Sequence

10 MVSSKVNSTW 20 CPASSFSSSS 30 VPTVKLFIDG 40 KFVESKSDKW 50 IDIHNPATNE 60 VVGRVPQSTK 70 AEMEAAVAAC 80 KRAFPAWADT 90 SILSRQQVLL 100 RYQQLIKENL 110 KEIARLITLE 120 QGKTLADAEG 130 DVFRGLQVVE 140 HACSVTSLML 150 GETMPSITKD 160 MDLYSYRLPL 170 GVCAGIAPFN 180 FPAMIPLWMF 190 PMAMVCGNTF 200 LMKPSERVPG 210 ATMLLAKLLQ 220 DSGAPDGTLN 230 IIHGQHEAVN 240 FICDHPDIKA 250 ISFVGSNQAG 260 EYIFERGSRN 270 GKRVQANMGA 280 KNHGVVMPDA 290 NKENTLNQLV 300 GAAFGAAGQR 310 CMALSTAVLV 320 GEAKKWLPEL 330 VERAKNLRVN 340 AGDQPGADLG 350 PLITPQAKER 360 VCNLIDSGAK 370 EGASILLDGR 380 KIKVKGYENG 390 NFVGPTIISN 400 VKPSMTCYKE 410 EIFGPVLVVL 420 ETETLDEAIK 430 IVNDNPYGNG 440 TAIFTTNGAI 450 ARKYAHMVDV 460 GQVGVNVPIP 470 VPLPMFSFTG 480 SRSSFRGDTN 490 FYGKQGIQFY 500 TQLKTITSQW 510 KEEDATLSSP AVVMPTMGR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Biological Process GO:0006574 L-valine catabolic process
Biological Process GO:0006210 thymine catabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.