Search Results

Overview

Uniprot IDA0A8I5ZJ51
Protein NameUnconventional myosin-Va
Gene NameMyo5a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1017 EERADKYKQETEQLV
1232 LRKALSEKSAPEVTA
389 TATETYIKPISKLQA
55 LEYRLDPKTSELPHL
621 RVPVKPTKGRPGQTA

Function

Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation

Protein Sequence

10 MAASELYTKF 20 ARVWIPDPEE 30 VWKSAELLKD 40 YKPGDKVLLL 50 HLEEGKDLEY 60 RLDPKTSELP 70 HLRNPDILVG 80 ENDLTALSYL 90 HEPAVLHNLR 100 VRFIDSKLIY 110 TYCGIVLVAI 120 NPYEQLPIYG 130 EDIINAYSGQ 140 NMGDMDPHIF 150 AVAEEAYKQM 160 ARDERNQSII 170 VSGESGAGKT 180 VSAKYAMRYF 190 ATVSGSASEA 200 NVEEKVLASN 210 PIMESIGNAK 220 TTRNDNSSRF 230 GKYIEIGFDK 240 RYRIIGANMR 250 TYLLEKSRVV 260 FQAEEERNYH 270 IFYQLCASAK 280 LPEFKMLRLG 290 NADSFHYTKQ 300 GGSPMIEGVD 310 DAKEMAHTRQ 320 ACTLLGISES 330 YQMGIFRILA 340 GILHLGNVGF 350 ASRDSDSCTI 360 PPKHEPLIIF 370 CDLMGVDYEE 380 MCHWLCHRKL 390 ATATETYIKP 400 ISKLQATNAR 410 DALAKHIYAK 420 LFNWIVGHVN 430 QALHSAVKQH 440 SFIGVLDIYG 450 FETFEINSFE 460 QFCINYANEK 470 LQQQFNMHVF 480 KLEQEEYMKE 490 QIPWTLIDFY 500 DNQPCINLIE 510 SKLGILDLLD 520 EECKMPKGTD 530 DTWAQKLYNT 540 HLNKCALFEK 550 PRMSNKAFII 560 KHFADKVEYQ 570 CEGFLEKNKD 580 TVFEEQIKVL 590 KSSKFKMLPE 600 LFQDDEKAIS 610 PTSATSSGRT 620 PLTRVPVKPT 630 KGRPGQTAKE 640 HKKTVGLQFR 650 NSLHLLMETL 660 NATTPHYVRC 670 IKPNDFKFPF 680 TFDEKRAVQQ 690 LRACGVLETI 700 RISAAGFPSR 710 WTYQEFFSRY 720 RVLMKQKDVL 730 GDRKQTCQNV 740 LEKLILDKDK 750 YQFGKTKIFF 760 RAGQVAYLEK 770 LRADKLRAAC 780 IRIQKTIRGW 790 LLRKRYLCMQ 800 RAAITVQRYV 810 RGYQARCYAK 820 FLRRTKAATT 830 IQKYWRMYVV 840 RRKYKIRRAA 850 TIVLQSYLRG 860 YLARNRYRKI 870 LREHKAVIIQ 880 KRVRGWLART 890 HYKRTMKAII 900 YLQCCFRRMM 910 AKRELKKLKI 920 EARSVERYKK 930 LHIGMENKIM 940 QLQRKVDEQN 950 KDYKCLMEKL 960 TNLEGVYNSE 970 TEKLRNDVER 980 LQLSEEEAKV 990 ATGRVLSLQE 1000 EIAKLRKDLE 1010 QTRSEKKSIE 1020 ERADKYKQET 1030 EQLVSNLKEE 1040 NTLLKQEKET 1050 LNHLMVEQAK 1060 EMTETMERKL 1070 VEETKQLELD 1080 LNDERLRYQN 1090 LLNEFSRLEE 1100 RYDDLKEEMT 1110 LMLNVPKPGH 1120 KRTDSTHSSN 1130 ESEYTFSSEF 1140 AETEDIAPRT 1150 EEPTEKKVPL 1160 DMSLFLKLQK 1170 RVTELEQEKQ 1180 LMQDELDRKE 1190 EQVLRSKAKE 1200 EERPQIRGAE 1210 LEYESLKRQE 1220 LESENKKLKN 1230 ELNELRKALS 1240 EKSAPEVTAP 1250 GAPAYRVLME 1260 QLTAVSEELD 1270 VRKEEVLILR 1280 SQLVSQKEAI 1290 QPKNTMTDST 1300 ILLEDVQKMK 1310 DKGEIAQAYI 1320 GLKETNRSSA 1330 MDYQELNEDG 1340 ELWLVYEGLK 1350 QANRLLESQL 1360 QSQKRSHENE 1370 AEALRGEIQS 1380 LKEENNRQQQ 1390 LLAQNLQLPP 1400 EARIEASLQH 1410 EITRLTNENL 1420 YFEELYADDP 1430 KKYQSYRISL 1440 YKRMIDLMEQ 1450 LEKQDKTVRK 1460 LKKQLKVFAK 1470 KIGELEVGQM 1480 ENISPGQIID 1490 EPIRPVNIPR 1500 KEKDFQGMLE 1510 YKREDEQKLV 1520 KNLILELKPR 1530 GVAVNLIPGL 1540 PAYILFMCVR 1550 HADYLNDDQK 1560 VRSLLTSTIN 1570 SIKKVLKKRG 1580 DDFETVSFWL 1590 SNTCRFLHCL 1600 KQYSGEEGFM 1610 KHNTSRQNEH 1620 CLTNFDLAEY 1630 RQVLSDLAIQ 1640 IYQQLVRVLE 1650 NILQPMIVSG 1660 MLEHETIQGV 1670 SGVKPTGLRK 1680 RTSSIADEGT 1690 YTLDSILRQL 1700 NSFHSVMCQH 1710 GMDPELIKQV 1720 VKQMFYIVGA 1730 ITLNNLLLRK 1740 DMCSWSKGMQ 1750 IRYNVSQLEE 1760 WLRDKNLMNS 1770 GAKETLEPLI 1780 QAAQLLQVKK 1790 KTDDDAEAIC 1800 SMCNALTTAQ 1810 IVKVLNLYTP 1820 VNEFEERVSV 1830 SFIRTIQVRL 1840 RDRKDSPQLL 1850 MDAKHIFPVT 1860 FPFNPSSLAL 1870 ETIQIPASLG LGFIARV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005884 actin filament
Cellular Component GO:0042641 actomyosin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0032433 filopodium tip
Cellular Component GO:0005770 late endosome
Cellular Component GO:0005764 lysosome
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0016459 myosin complex
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005777 peroxisome
Cellular Component GO:0098871 postsynaptic actin cytoskeleton
Cellular Component GO:0055037 recycling endosome
Cellular Component GO:0001726 ruffle
Cellular Component GO:0030141 secretory granule
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0018958 phenol-containing compound metabolic process
Biological Process GO:0043473 pigmentation
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0006892 post-Golgi vesicle-mediated transport
Biological Process GO:0015031 protein transport
Biological Process GO:0032252 secretory granule localization
Biological Process GO:0030050 vesicle transport along actin filament

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.