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Overview

Uniprot ID	A0A8I5ZK83
Protein Name	General transcription factor II-I
Gene Name	Gtf2i
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
308	VREFNFEKWNARITD

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSALP 20 AEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKCTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVAV 160 QGLPEGVAFK 170 HPEHYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 AADADRPMLS 220 PGGSCGPIKV 230 KTEPTEDSGS 240 HHSSEGNEGA 250 EVEVPAEDST 260 QHVPSETSED 270 PEVEVTIEDD 280 DYSPPTKRPK 290 SSEPPPPPPV 300 PEPTNAGKRK 310 VREFNFEKWN 320 ARITDLRKQV 330 EELFERKYAQ 340 AIKAKGPVTI 350 PYPLFQSHVE 360 DLYVEGLPEG 370 IPFRRPSTYG 380 IPRLERILLA 390 KERIRFVIKK 400 HELLNSTRED 410 LQLDKPASGV 420 KEEWYARITK 430 LRKMVDQLFC 440 KKFAEALGST 450 EAKAVPYQKF 460 EAYPNDLYVE 470 GLPENIPFRS 480 PSWYGIPRLE 490 KIIQVGNRIK 500 FVIKRPELLT 510 HSTTEVTQPR 520 TNTPVKEDWN 530 VRITKLRKQV 540 EEIFNLKFAQ 550 ALGLTEAVKV 560 PYPVFESNPE 570 FLYVEGLPEG 580 IPFRSPTWFG 590 IPRLERIVRG 600 SNKIKFVVKK 610 PELVVSYLPP 620 GMASKINTKA 630 LQSPKRPRSP 640 GSNSKVPEIE 650 VTVEGPNNNS 660 PQTSTVRTPT 670 QTNGSNVPFK 680 PRGREFSFEA 690 WNAKITDLKQ 700 KVENLFNEKC 710 GEALGLKQAV 720 KVPFALFESF 730 PEDFYVEGLP 740 EGVPFRRPST 750 FGIPRLEKIL 760 RNKAKIKFII 770 KKPEMFETAI 780 KESTSSKSPP 790 RKTNSSPSVN 800 TTASGVEDLN 810 IIQVTIPDDD 820 NERLSKVEKA 830 RQLREQVNDL 840 FSRKFGEAIG 850 MGFPVKVPYR 860 KITINPGCVV 870 VDGMPPGVSF 880 KAPSYLEISS 890 MRRILDSAEF 900 IKFTVIRPFP 910 GLVINNQLVD 920 QNESEGPVIQ 930 ESAEASQLEV 940 PATEEIKETD 950 GSSQIKQEPD PTW

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006366	transcription by RNA polymerase II

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.