Search Results
Overview
| Uniprot ID | A0A8I5ZKU7 |
|---|---|
| Protein Name | Isovaleryl-CoA dehydrogenase, mitochondrial |
| Gene Name | Ivd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 56 | QLRHTISKFVQENLA |
| 76 | IDQSNDFKNLREFWK |
Function
A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor
Protein Sequence
10
MATAVRLLGR
20
RVSSWRLRPL
30
PSPLAVPQRA
40
HSMLPVDDDI
50
NGLNEEQKQL
60
RHTISKFVQE
70
NLAPKAQEID
80
QSNDFKNLRE
90
FWKQLGSLGV
100
LGITAPVQYG
110
GSGLGYLEHV
120
LVMEEISRAS
130
AAVGLSYGAH
140
SNLCINQIVR
150
NGNEAQKEKY
160
LPKLISGEFI
170
GALAMSEPNA
180
GSDVVSMRLK
190
AEKKGDHYVL
200
NGNKFWITNG
210
PDADVLVVYA
220
KTDLTAVPAS
230
RGITAFIVEK
240
VSVVGPLTSV
250
YPAAANILSQ
260
ESKGVYVLMS
270
GLDLERLVLA
280
GGPLGIMQAV
290
LDHTIPYLHV
300
REAFGQKIGQ
310
FQLMQGKMAD
320
MYTRLMACRQ
330
YVYNVARACD
340
EGHITAKDCA
350
GVILYTAECA
360
TQVALDGIQC
370
LGGNGYINDF
380
PMGRFLRDAK
390
LYEIGGGTSE
400
VRRLVIGRAF
NADFR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008470 | 3-methylbutanoyl-CoA dehydrogenase activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Biological Process | GO:0046395 | carboxylic acid catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.