Search Results
Overview
| Uniprot ID | A0A8I5ZL23 |
|---|---|
| Protein Name | 3-hydroxyisobutyryl-CoA hydrolase |
| Gene Name | Hibch |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 294 | PFAMEQIKVINKMSP |
| 350 | VRAVLIDKDQTPKWK |
| 89 | IIKGAGGKAFCAGGD |
Function
Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA
Protein Sequence
10
MRELPHEGKR
20
FSSIRRASVI
30
LQHLRMSKHT
40
ETAEVLLERR
50
GCAGVITLNR
60
PKLLNALSLN
70
MIRQIYPQLK
80
KWERDPDTFL
90
IIIKGAGGKA
100
FCAGGDIKAL
110
SEAKKAGQTL
120
SQDLFREEYI
130
LNNAIASCQK
140
PYVALIDGIT
150
MGGGVGLSVH
160
GQFRVATERS
170
LFAMPETGIG
180
LFPDVGGGYF
190
LPRLQGKLGY
200
FLALTGFRLK
210
GRDVHRAGIA
220
THFVDSEKLH
230
VLEEELLALK
240
SPSAEDVAGV
250
LESYHAKSKM
260
GQDKSIIFEE
270
HMDKINSCFS
280
ANTVEQILEN
290
LRQDGSPFAM
300
EQIKVINKMS
310
PTSLKITLRQ
320
LMEGSTKTLQ
330
EVLTMEYRLT
340
QACMEGHDFH
350
EGVRAVLIDK
360
DQTPKWKPAD
370
LKDVTDEDLN
380
SYFKSLGSRD
LKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity |
| Biological Process | GO:0006574 | L-valine catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.