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Overview

Uniprot ID	A0A8I5ZL32
Protein Name	CLIP-associating protein 1
Gene Name	Clasp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
286	MASSLGSKSSAAKEG

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMESCLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVVLLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGICLC 160 LIATLNASGA 170 QTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMIQSANDKN 250 FDDEDSVDGN 260 RPSSASSSSS 270 KAPSSSRRNV 280 SMGTTRRLMA 290 SSLGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIVSLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTASR 590 GSTVSTKSMS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVSSSSGS 630 TAFSSAAALP 640 PGSYASLGRI 650 RTRRQSSGST 660 TNVASTSSDS 670 RGRSRAKVVS 680 QSQRSRSANP 690 AGAGSRSSSP 700 GKLLGSGYGG 710 LAGGSSRGPP 720 VTPSSEKRSK 730 IPRSQGCSRE 740 TSPNRIGLDR 750 FGLGQSGRIP 760 GSVSAMRVLS 770 TSTDLEAAVA 780 DALLLGDARS 790 KKKPVRRRYE 800 PYGMYSDDDA 810 NSDASSVCSE 820 RSYGSRNGGI 830 PHYLRQTEDV 840 AEVLNHCASS 850 NWSERKEGLL 860 GLQNLLKSQR 870 TLSRVELKRL 880 CEIFTRMFAD 890 PHSKIADSEA 900 ECEDKEGNLF 910 PSEGSCPRVF 920 SMFLETLVDF 930 IIIHKDDLQD 940 WLFVLLTQLL 950 KKMGADLLGS 960 VQAKVQKALD 970 VTRDSFPFDQ 980 QFNILMRFIV 990 DQTQTPNLKV 1000 KVAILKYIES 1010 LARQMDPTDF 1020 VNSSETRLAV 1030 SRIITWTTEP 1040 KSSDVRKAAQ 1050 IVLISLFELN 1060 TPEFTMLLGA 1070 LPKTFQDGAT 1080 KLLHNHLKNS 1090 SNAGVGSPSN 1100 TIGRTPSRHP 1110 SSRTSPLTSP 1120 TNCSHGGLSP 1130 SMLDYDTENL 1140 NSEEIYSSLR 1150 GVTEAIEKFS 1160 FRSQEDLNEP 1170 IKRDGKKDCD 1180 IVSRDGGAAS 1190 PATEGRGGSE 1200 VEGGRMALDN 1210 KTSLLNTQPP 1220 RAFPGPRARE 1230 YNPYPYSDTI 1240 NTYDKTALKE 1250 AVFDDDMEQL 1260 RDVPIDHSDL 1270 VADLLKELSN 1280 HNERVEERKG 1290 ALLELLKITR 1300 EDSLGVWEEH 1310 FKTILLLLLE 1320 TLGDKDHSIR 1330 ALALRVLREI 1340 LRNQPARFKN 1350 YAELTIMKTL 1360 EAHKDSHKEV 1370 VRAAEEAAST 1380 LASSIHPEQC 1390 IKVLCPIIQT 1400 ADYPINLAAI 1410 KMQTKVVERI 1420 TKESLLQLLV 1430 DIIPGLLQGY 1440 DNTESSVRKA 1450 SVFCLVAIYS 1460 VIGEDLKPHL 1470 AQLTGSKMKL 1480 LNLYIKRAQT 1490 TNSNSSSSSD VSTHS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0007026	negative regulation of microtubule depolymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.