Search Results
Overview
| Uniprot ID | A0A8I5ZL60 |
|---|---|
| Protein Name | SUMO-activating enzyme subunit 1 |
| Gene Name | Sae1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 186 | EEKTKVTKVSQGVED |
| 201 | GPDAKRAKLDSSETT |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2
Protein Sequence
10
MVEKEEVSGG
20
GGGISEEEAA
30
QYDRQIRLWG
40
LEAQKRLRAS
50
RVLIVGMKGL
60
GAEIAKNLIL
70
AGVKGLTMLD
80
HEQVSPEDLG
90
AQFLIRTGSV
100
GQNRAEASLE
110
RAQNLNPMVD
120
VKVDTEDIEK
130
KPESFFTEFD
140
AVCLTCCSKD
150
VIIKVDQICH
160
RNSIKFFTGD
170
VFGYHGYTFA
180
NLGEHEFVEE
190
KTKVTKVSQG
200
VEDGPDAKRA
210
KLDSSETTMV
220
KKKVLFCPVK
230
EALAVDWSGE
240
KAQAALKRTA
250
PDYFLLQVLL
260
KFRTDKGRDP
270
TSDSYSEDAE
280
LLLQIRNDVF
290
DSLGVSPDLL
300
PDDFVRLASA
310
QTGVCVGPCL
320
KGTLLTTTSS
SSMA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031510 | SUMO activating enzyme complex |
| Molecular Function | GO:0008641 | ubiquitin-like modifier activating enzyme activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.