Search Results

Overview

Uniprot ID	A0A8I5ZLT6
Protein Name	Aconitate hydratase, mitochondrial
Gene Name	Aco2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
517	ETDFLTGKDGKKFKL
520	FLTGKDGKKFKLEAP

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate

Protein Sequence

10 MAPYSLLVTR 20 LQKALGVRQY 30 HVASALCQRA 40 KVAMSHFEPS 50 EYIRYDLLEK 60 NINIVRKRLN 70 RPLTLSEKIV 80 YGHLDDPANQ 90 EIERGKTYLR 100 LRPDRVAMQD 110 ATAQMAMLQF 120 ISSGLPKVAV 130 PSTIHCDHLI 140 EAQLGGEKDL 150 RRAKDINQEV 160 YNFLATAGAK 170 YGVGFWRPGS 180 GIIHQIILEN 190 YAYPGVLLIG 200 TDSHTPNGGG 210 LGGICIGVGG 220 ADAVDVMAGI 230 PWELKCPKVI 240 GVKLTGTLSG 250 WTSPKDVILK 260 VAGILTVKGG 270 TGAIVEYHGP 280 GVDSISCTGM 290 ATICNMGAEI 300 GATTSVFPYN 310 HRMKKYLSKT 320 GRADIANLAE 330 EFKDHLVPDP 340 GCQYDQVIEI 350 NLNELKPHIN 360 GPFTPDLAHP 370 VADVGTVAEK 380 EGWPLDIRVG 390 LIGSCTNSSY 400 EDMGRSAAVA 410 KQALAHGLKC 420 KSQFTITPGS 430 EQIRATIERD 440 GYAQILRDVG 450 GIVLANACGP 460 CIGQWDRKDI 470 KKGEKNTIVT 480 SYNRNFTGRN 490 DANPETHAFV 500 TSPEIVTALA 510 IAGTLKFNPE 520 TDFLTGKDGK 530 KFKLEAPDAD 540 ELPRSVKGKC 550 TTDHISAAGP 560 WLKFRGHLDN 570 ISNNLLIGAI 580 NIENGKANSV 590 RNAVTQEFGP 600 VPDTARYYKK 610 HGIRWVVIGD 620 ENYGEGSSRE 630 HAALEPRHLG 640 GRAIITKSFA 650 RIHETNLKKQ 660 GLLPLTFADP 670 SDYNKIHPVD 680 KLTIQGLKDF 690 APGKPLNCII 700 KHPNGTQETI 710 LLNHTFNETQ 720 IEWFRAGSAL NRMKELQQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0051539	4 iron, 4 sulfur cluster binding
Molecular Function	GO:0003994	aconitate hydratase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006099	tricarboxylic acid cycle

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.