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Overview

Uniprot IDA0A8I5ZMZ1
Protein NameOxaloacetate tautomerase FAHD2A, mitochondrial
Gene NameFahd2a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
186 EQNVRVPKNPIIFSK
260 DWQMRNGKQWLLGKT
345 PGVGMFRKPPVFLKK

Function

Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition

Protein Sequence

10 MATAGGGGGA 20 ISLGEELSAC 30 LLRSWLWLLC 40 PPLSTCSLAG 50 IGSLHREPGG 60 SGHSKQALML 70 GSGRRRLLST 80 LLQVQKRPCQ 90 PCRNMRLVQF 100 QAPHLEEPHV 110 GLESGIGGGV 120 VDLNTFDPAL 130 PKTMVQFLER 140 GETALSVARR 150 ALAAQLPLIP 160 RSQVTFLAPV 170 TRPDKVICVG 180 LNYADHCQEQ 190 NVRVPKNPII 200 FSKFSSSIVG 210 PYDSIILPPE 220 SKEVDWEVEM 230 AVVIGKKGKH 240 IKATDVMAYV 250 AGFTVAHDVS 260 ARDWQMRNGK 270 QWLLGKTFDT 280 FCPLGPALVT 290 KDTIADPHNL 300 KISCRVNGEI 310 VQSSNTNQMV 320 FKTEDLIAWV 330 SQFVTLYPGD 340 ILLTGTPPGV 350 GMFRKPPVFL 360 KKGDEVQCEI 370 EELGVIINKV V

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0050163 oxaloacetate tautomerase activity
Biological Process GO:0006107 oxaloacetate metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.