Search Results
Overview
| Uniprot ID | A0A8I5ZN97 |
|---|---|
| Protein Name | Tubulin alpha chain |
| Gene Name | Tuba8 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 139 | LVLDRIRKLTDACSG |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Protein Sequence
10
MEPRGCSWTA
20
VSKKLPRECI
30
SVHVGQAGVQ
40
IGNACWELFC
50
LEHGIQADGT
60
FGTQASKIND
70
DDSFTTFFSE
80
TGNGKHVPRA
90
VMVDLEPTVV
100
DEVRAGTYRQ
110
LFHPEQLITG
120
KEDAANNYAR
130
GHYTVGKESI
140
DLVLDRIRKL
150
TDACSGLQGF
160
LIFHSFGGGT
170
GSGFTSLLME
180
RLSLDYGKKS
190
KLEFAIYPAP
200
QVSTAVVEPY
210
NSILTTHTTL
220
EHSDCAFMVD
230
NEAIYDICRR
240
NLDIERPTYT
250
NLNRLISQIV
260
SSITASLRFD
270
GALNVDLTEF
280
QTNLVPYPRI
290
HFPLVTYAPI
300
VSAEKAYHEQ
310
LSVAEITSSC
320
FEPNSQMVKC
330
DPRHGKYMAC
340
CMLYRGDVVP
350
KDVNVAIAAI
360
KTKRTIQFVD
370
WCPTGFKVGI
380
NYQPPTVVPG
390
GDLAKVQRAV
400
CMLSNTTAIA
410
EAWARLDHKF
420
DLMYAKRAFV
430
HWYVGEGMEE
440
GEFSEAREDL
450
AALEKDYEEV
460
GTDSFEEENE
GEEF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005874 | microtubule |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.