Search Results
Overview
| Uniprot ID | A0A8I5ZNB5 |
|---|---|
| Protein Name | ATP-dependent (S)-NAD(P)H-hydrate dehydratase |
| Gene Name | Naxd |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 85 | IVPALTSKKHKGQDG |
Function
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Protein Sequence
10
MGIRCVAIRA
20
CGGGKIDTGV
30
PRMAVCPYGA
40
AAVVMALLSA
50
AIAFHCSPLL
60
AVLQRALSLH
70
TAHATKDMDN
80
LFQLVRNIVP
90
ALTSKKHKGQ
100
DGRIGIVGGC
110
QEGPPPACLS
120
GADLTHVFCA
130
REAAPVIKSY
140
SPELIVHPVL
150
DSSDAVEEVE
160
KWLPRLHALV
170
VGPGLGRDDL
180
LLNNVRGILE
190
STKARDIPVV
200
IDADGLWLIA
210
QRPALVHGYQ
220
KAVLTPNHVE
230
FSRLWDAVLS
240
SPMDTSNHSG
250
SVLKLSQALG
260
NITIVQKGEQ
270
DLISNGQQVL
280
VCNQEGSSRR
290
CGGQGDLLSG
300
SLGVMAHWAL
310
RAGPEKTNGS
320
SPLLVAAWGA
330
CTLTRECNHL
340
AFQKYGRSTT
350
TTDMIAEVGA
AFSKLFTT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0047453 | ATP-dependent NAD(P)H-hydrate dehydratase activity |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.