Search Results
Overview
| Uniprot ID | A0A8I5ZQ44 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | Dctn2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | VKETPQQKYQRLLHE |
| 127 | EKIKTTVKESATEEK |
| 134 | KESATEEKLTPVVLA |
| 148 | AKQLAALKQQLVASH |
| 226 | DKFSQAAKVAELEKR |
| 300 | VNEIAKHKASVEDAD |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MADPKYADLP
20
GIARNEPDVY
30
ETSDLPEDDQ
40
AEFDAGEEEL
50
SSTSVEHIIV
60
NPNAAYDKFK
70
DKRVGTKGLD
80
FSDRIGKTKR
90
TGYESGDYEM
100
LGEGLGVKET
110
PQQKYQRLLH
120
EVQELTTEVE
130
KIKTTVKESA
140
TEEKLTPVVL
150
AKQLAALKQQ
160
LVASHLEKLL
170
GPDAAINLAD
180
PDGALAKRLL
190
LQLEATKSSK
200
GSSGGKSTGG
210
TPPDSSLVTY
220
ELHSRPEQDK
230
FSQAAKVAEL
240
EKRLTELEAT
250
VRCDQDAQNP
260
LSAGLQGACL
270
METVELLQAK
280
VNALDLAVLD
290
QVEARLQSVL
300
GKVNEIAKHK
310
ASVEDADTQN
320
KVHQLYETIQ
330
RWSPVASTLP
340
ELVQRLVTIK
350
QLHEQAMQFG
360
QLLTHLDTTQ
370
QMMASSLKDN
380
TALLTQVQTT
390
MRENLATVEG
400
NFASIDARMK
KLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.