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Overview

Uniprot IDA0A8I5ZQ56
Protein NameSplicing factor 1
Gene NameSf1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
18 DFPSKKRKRSRWNQD

Function

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor

Protein Sequence

10 MATGANATPL 20 DFPSKKRKRS 30 RWNQDTMEQK 40 TVIPGMPTVI 50 PPGLTREQER 60 AYIVQLQIED 70 LTRKLRTGDL 80 GIPPNPEDRS 90 PSPEPIYNSE 100 GKRLNTREFR 110 TRKKLEEERH 120 TLITEMVALN 130 PDFKPPADYK 140 PPATRVSDKV 150 MIPQDEYPEI 160 NFVGLLIGPR 170 GNTLKNIEKE 180 CNAKIMIRGK 190 GSVKEGKVGR 200 KDGQMLPGED 210 EPLHALVTAN 220 TMENVKKAVE 230 QIRNILKQGI 240 ETPEDQNDLR 250 KMQLRELARL 260 NGTLREDDNR 270 ILRPWQSSET 280 RSITNTTVCT 290 KCGGAGHIAS 300 DCKFQRPGDP 310 QSAQDKARMD 320 KEYLSLMAEL 330 GEAPVPASVG 340 STSGPATTPL 350 ASAPRPAAPA 360 SNPPPPSLMS 370 TTQSRPPWMN 380 SGPSENRPYH 390 GMHGGGPGGP 400 GGGPHSFPHP 410 LPSLTGGHGG 420 HPMQHNPNGP 430 PPPWMQPPPP 440 PMNQGPHPPG 450 HHGPPPMGKS 460 VPGKYACGLW 470 GLSPASRKRY 480 DAAAAYGHDA 490 AASATSQWAA 500 PASSLWSSSS 510 MAAAAAAAST 520 TPSAQQQYGF 530 QHPLAMAAKI 540 PPRSSDGPSH 550 ESEDFPRPLV 560 TLPGRQPQQR 570 PWWTGWFGKA A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0045131 pre-mRNA branch point binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0080090 regulation of primary metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.