Search Results
Overview
| Uniprot ID | A0A8I5ZQL5 |
|---|---|
| Protein Name | Isobutyryl-CoA dehydrogenase, mitochondrial |
| Gene Name | Acad8 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 211 | RTGGSGPKGISCIVV |
Function
Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway. To a lesser extent, also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA
Protein Sequence
10
VAMLRTGSRR
20
LGCLRAALQS
30
LAQTDHRSIT
40
FCIDPSLGLN
50
EEQKGFQKVA
60
FDFAAREMAP
70
NMAEWDQKEL
80
FPVDVMRKAA
90
QLGFGGIYVR
100
TDVGGSGLSR
110
LDTSVIFEAL
120
ATGCTSTTAY
130
ISIHNMCAWM
140
IDSFGNEEQR
150
HKFCPPLCTM
160
EKFASYCLTE
170
PGSGSDAASL
180
LTSAKRQGDH
190
YILNGSKAFI
200
SGGGESDIYV
210
VMCRTGGSGP
220
KGISCIVVEK
230
GTPGLSFGKK
240
EKKVGWNSQP
250
TRAVIFEDCA
260
VPVANRIGTE
270
GQGFLIAMKG
280
LNGGRINVAS
290
CSLGAAHASV
300
VLTQEHLKVR
310
KQFGAPLARS
320
QYLQFQLADM
330
ATKLVASRLM
340
IRTAAVALQE
350
EREDAVALCS
360
MAKLFVTEEC
370
FTICNQALQM
380
HGGYGYLKDY
390
AVQQYMRDSR
400
VHQILEGSNE
410
VMRMLISRSL
LQD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0003853 | short-chain 2-methyl fatty acyl-CoA dehydrogenase activity |
| Biological Process | GO:0009083 | branched-chain amino acid catabolic process |
| Biological Process | GO:0006635 | fatty acid beta-oxidation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.