Search Results
Overview
| Uniprot ID | A0A8I5ZR41 |
|---|---|
| Protein Name | Ferrochelatase |
| Gene Name | Fech |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 51 | AHHAKTTKPQAQPER |
Function
Catalyzes the ferrous insertion into protoporphyrin IX
Protein Sequence
10
MLTLWLVGLP
20
LRAPKGPVVY
30
GSSRACQPWR
40
CQSGPAVVAT
50
TEKAHHAKTT
60
KPQAQPERRK
70
PKTGILMLNM
80
GGPETLGEVQ
90
DFLQRLFLDR
100
DLMTLPIQNK
110
LAPFIAKRRT
120
PKIQEQYRRI
130
GGGSPIKMWT
140
SKQGEGMVKL
150
LDELSPDTAP
160
HKYYIGFRYV
170
HPLTEEAIEE
180
MERDGLERAI
190
AFTQYPQYSC
200
STTGSSLNAI
210
YRYYNEVGRK
220
PTMKWSTIDR
230
WPTHPLLIQC
240
FADHILKELD
250
HFPEEKRSEV
260
VILFSAHSLP
270
MSVVNRGDPY
280
PQEVGATVHR
290
VMEQLGYPNP
300
YRLVWQSKVG
310
PVPWLGPQTD
320
EAIKGLCERG
330
RKNILLVPIA
340
FTSDHIETLY
350
ELDIEYSQVL
360
AQKCGAENIR
370
RAESLNGNPL
380
FSKALADLVH
390
SHIQSNKLCS
400
TQLSLSCPLC
410
VNPVCRKTKS
FFTSQQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0004325 | ferrochelatase activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Biological Process | GO:0006785 | heme B biosynthetic process |
| Biological Process | GO:0046501 | protoporphyrinogen IX metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.