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Overview

Uniprot IDA0A8I5ZRK2
Protein NameMitochondrial glutamate carrier 2
Gene NameSlc25a18
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
54 RLQNQQGKDVYKGMT

Function

Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system)

Protein Sequence

10 FLACNLLSHF 20 LFFSSPWPSI 30 TAKLINGGIA 40 GLVGVTCVFP 50 IDLAKTRLQN 60 QQGKDVYKGM 70 TDCLVKTARA 80 EGFLGMYRGA 90 AVNLTLVTPE 100 KAIKLAANDF 110 LRQLLMQDGT 120 QRNLKMEMLA 130 GCGAGICQVV 140 ITCPMEMLKI 150 QLQDAGRLAV 160 CQQASASATP 170 TSRPYSTGST 180 STHRRPSATL 190 IAWELLRTQG 200 LSGLYRGLGA 210 TLLRDIPFSI 220 IYFPLFANLN 230 QLGVSELTGK 240 ASFTHSFVAG 250 CAAGSVSAVA 260 VTPLDVLKTR 270 IQTLKKGLGE 280 DTYRGVTDCA 290 RKLWTQEGAA 300 AFMKGAGCRA 310 LVIAPLFGIA 320 QGVYFIGIGE RILKCFE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0005280 amino acid:proton symporter activity
Biological Process GO:0015813 L-glutamate transmembrane transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.