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Overview

Uniprot ID	A0A8I5ZT50
Protein Name	Protein enabled homolog
Gene Name	Enah
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
694	RRRRIAEKGSTIETE

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation

Protein Sequence

10 MSEQSICQAR 20 AAVMVYDDAN 30 KKWVPAGGST 40 GFSRVHIYHH 50 TGNNTFRVVG 60 RKIQDHQVVI 70 NCAIPKGLKY 80 NQATQTFHQW 90 RDARQVYGLN 100 FGSKEDANVF 110 ASAMMHALEV 120 LNSQEAAQSK 130 VTATQDSTNL 140 RCIFCGPTLP 150 RQNSQLPAQV 160 QNGPSQEEME 170 IQRRQLQEQQ 180 RQKELERERM 190 ERERLERERL 200 ERERLERERL 210 EQEQLERQRQ 220 EREHVERLER 230 ERLERLERER 240 QDRERERERL 250 EQLEREQVEW 260 ERERRMSNAA 270 PSSDSSLYSA 280 PLPEYSSCQP 290 PSAPPPSYAK 300 VISAPVSDAA 310 PDYAVVTALP 320 PTSTPPTPPL 330 RHSATRFATS 340 LGSAFHPVLP 350 HYATVPRPLN 360 RNSRPSSPVN 370 TPSSQPPAAK 380 SCAWPTSNFS 390 PLPPSPPIMI 400 SSPPGKATGP 410 RPVLPVCVSS 420 PVPQMPPSPT 430 APNGSLDSVT 440 YPVSPPPTSG 450 PAAPPPPPPP 460 PPPPPPPPPP 470 PPLPPLASLS 480 HCGSQASPPP 490 GTPLASTPSS 500 KPSVLPSPSA 510 AAPASVETPL 520 NPELGDSSAS 530 EPGLQAASQP 540 AETPAPQGHV 550 LGPPAPPPPP 560 PLPSGPAYAS 570 ALPPPPGPPP 580 PPPLPSAGPP 590 PPPPPPPPLP 600 NQVPPPPPPP 610 PAPPLPASGI 620 FSGSMSEDNR 630 PLTGLAAAIA 640 GAKLRKVSRV 650 EDGSFPSGGN 660 TVSVNLASSK 670 TDSGRGNGPL 680 PLGGSGLMEE 690 MSALLARRRR 700 IAEKGSTIET 710 EQKEDRSEDA 720 EPVTSKAAST 730 STPEPTRKPW 740 ERTNTMNGSK 750 SPVISRPKST 760 PSSQPSANGV 770 QTEGLDYDRL 780 KQDILDEMRK 790 ELAKLKEELI 800 DAIRQELSKS NTA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005856	cytoskeleton
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030175	filopodium
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0045202	synapse
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0017124	SH3 domain binding
Biological Process	GO:0001843	neural tube closure

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.